Molecular Epidemiology of Enteric Adenovirus Gastroenteritis in under-Five-Year-Old Children in Iran
Molecular Epidemiology of Enteric Adenovirus Gastroenteritis in under-Five-Year-Old Children in Iran
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DOI：
10.1155/2016/2045697
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发表时间：
2016-01-01
影响因子：
2
通讯作者：
Karimi, Abdollah
中科院分区：
文献类型：
--
作者：
Dashti, Anahita Sanaei;Ghahremani, Pedram;Karimi, Abdollah
背景急性胃肠炎是发达国家和发展中国家幼儿发病率和死亡率的主要来源之一。本研究的目的是确定伊朗五个不同卫生中心因胃肠炎住院的儿童中人腺病毒-（HAdV-）40和HAdV-41的患病率。方法.在一项横断面流行病学研究中，我们研究了2012年2月至2013年2月在伊朗五个教育和治疗儿科中心收集的2682份5岁以下儿童粪便标本。采用聚合酶链反应（PCR）方法中的特异性引物对，对样本进行HAdV-40和HAdV-41检测。结果HAdV-40和HAdV-41共检出132例（5.18%）。与其他年龄组相比，在12个月以下的儿童中观察到HAdV-40和HAdV-41的患病率显著较高（58.3%）。男女比例为1.7。结论这项研究的结果表明，HAdV-40和HAdV-41可以被认为是伊朗儿童急性胃肠炎的病原体。PCR作为一种快速检测方法，可以增加相对温和的病程，然后完全康复的机会，并避免使用不必要的抗生素。
Background. Acute gastroenteritis is one of the major sources of morbidity and mortality among young children in developed and developing countries. The aim of this study was to determine the prevalence of human adenovirus- (HAdV-) 40 and HAdV-41 in children hospitalized with gastroenteritis in five different health centers of Iran. Methods. In a cross-sectional epidemiological study, we studied 2682 fecal specimens that were collected from children under the age of 5 years in five educational and therapeutic pediatric centers in Iran from February 2012 to February 2013. Samples were tested for HAdV-40 and HAdV-41, using a specific pair of primers in polymerase chain reaction (PCR) method. Results. HAdV-40 and HAdV-41 were detected in 132 (5.18%) of the patients with diarrhea. A significantly higher prevalence of HAdV-40 and HAdV-41 (58.3%) was observed in children under 12 months of age, compared to other age groups. The male to female ratio was 1.7. Conclusion. The results of this study demonstrated that HAdV-40 and HAdV-41 could be considered etiological agents for acute gastroenteritis among children in Iran. The PCR as a rapid test may increase the chance for a relatively mild course of the disease followed by a complete recovery and avoiding administration of unnecessary antibiotics.