Thermoreceptive innervation of human glabrous and hairy skin: a contact heat evoked potential analysis
Thermoreceptive innervation of human glabrous and hairy skin: a contact heat evoked potential analysis
复制标题
DOI：
10.1016/j.pain.2005.02.017
复制
发表时间：
2005-06-01
期刊：
影响因子：
7.4
通讯作者：
Casey, KL
中科院分区：
文献类型：
--
作者：
Granovsky, Y;Matre, D;Casey, KL
猴的神经生理学研究表明，无毛皮肤的低阈值热伤害感受器（AMH 2型）比有毛皮肤少。因此，我们用温控接触热诱发电位（CHEP）刺激器选择性地兴奋人的C纤维热感受器或AMH 2型受体。在手背上，51摄氏度的刺激产生疼痛的针刺感，41摄氏度的刺激引起温暖。在无毛鱼际，41 ℃刺激产生轻度温热，51 ℃刺激引起强烈但无痛的热感觉。我们用CHEP反应来估计介导这些感觉的外周纤维的传导速度（CV）。在多毛皮肤上，41 ℃刺激诱发由C纤维介导的超晚电位（平均SD N波潜伏期：455（118）ms）（回归分析CV：1.28 m/s）。N= 15），而51 ℃刺激诱发晚电位（N潜伏期：267（33）ms）介导的A δ传入（CV内的主题分析：12.9 m/s，N = 6）。相反，鱼际对41和51 'C的反应由C纤维介导（回归分析N波平均潜伏期分别为485（100）和433（73）ms，CV为0.95-1.35 m/s）。N= 15，平均CV = 1.7 ± 0.41）m/s，根据远端无毛和近端有毛皮肤刺激计算，N=6）。人类和猴子手掌的探索范围因低阈值C神经支配的热感受器的丰富和低阈值AMH 2型热伤害感受器的缺乏而增强。(c)2005年国际疼痛研究协会。Elsevier B. V.出版，保留所有权利。
The human palm has a lower heat detection threshold and a higher heat pain threshold than hairy skin, Neurophysiological studies of monkeys suggest that glabrous skin has fewer low threshold heat nociceptors (AMH type 2) than hairy skin, Accordingly, we used a temperature-controlled contact heat evoked potential (CHEP) stimulator to excite selectively heat receptors with C fibers or A delta-innervated AMH type 2 receptors in humans. On the dorsal hand, 51 degrees C Stimulation produced painful pinprick sensations and 41 degrees C stimuli evoked warmth. On the glabrous thenar, 41 degrees C stimulation produced mild warmth and 51 degrees C evoked strong but painless heat sensations, We used CHEP responses to estimate the conduction velocities (CV) of peripheral fibers mediating these sensations. On hairy skin, 41 degrees C stimuli evoked an ultra-late potential (mean, SD N wave latency: 455 (118) ms) mediated by C fibers (CV by regression analysis: 1.28 m/s. N= 15) whereas 51 degrees C stimuli evoked a late potential (N latency: 267(33) ms) mediated by A delta afferents (CV by within-subject analysis: 12.9 m/s, N = 6). In contrast, thenar responses to 41 and 51 'C were mediated by C fibers (average N wave latencies 485( 100) and 433(73) ms, respectively CVs 0.95-1.35 m/s by regression analysis. N= 15, average CV = 1.7 0.41) m/s calculated from distal glabrous and proximal hairy skin stimulation, N=6). The exploratory range of the human and monkey palm is enhanced by the abundance of low threshold, C-innervated heat receptors and the paucity of low threshold AMH type 2 heat nociceptors. (c) 2005 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.