Changes in metabolic profiles after the Great East Japan Earthquake: a retrospective observational study
Changes in metabolic profiles after the Great East Japan Earthquake: a retrospective observational study
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DOI：
10.1186/1471-2458-13-267
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发表时间：
2013-03-23
影响因子：
4.5
通讯作者：
Tachiya, Hidekiyo
中科院分区：
文献类型：
--
作者：
Tsubokura, Masaharu;Takita, Morihito;Tachiya, Hidekiyo
背景资料：2011年3月，日本东部海域发生里氏9.0级地震。许多幸存者因大海啸(海啸组)或福岛第一核电站(辐射组)核事故预期的高剂量辐射而失去房屋后，一直住在当地政府提供的临时房屋中。海啸高度超过9米，位于福岛第一核电站以北30公里处，毗邻强制疏散区域。2011年9月，在索马为撤离者举行了一次健康检查计划。这项研究的目的是比较灾难发生前后疏散人员的代谢情况。根据以往有关自然灾害的报道，我们假设疏散人员的代谢状况将会恶化。方法：对2010年9月或10月(震前)和2011年(震后)参加健康筛查的200名受试者的数据进行了回顾，并将其纳入本研究。对海啸组和辐射组的地震前和地震后的体检和实验室测试结果进行了比较。结果：与震前水平相比，震后筛查人群的体重、体重指数、腰围和HbA1c显著升高，而高密度脂蛋白胆固醇水平显著降低(p=0.004，p=0.03，p=0.008，p=0.001和p=0.03)。海啸组受试者HbA1c升高的比例在地震后(34.3%)明显高于地震前(14.8%)(p<；0.001)，定义为HbA1c=5.7%。多因素分析表明，地区性因素、定期就诊次数、地震前腰围是HbA1c恶化的预测因素。结论：与地震前相比，居住在临时房屋中的幸存者震后代谢指标受损。自然灾害可能会影响新陈代谢，应该为幸存者制定仔细的随访计划。
Background: A magnitude 9.0 earthquake struck off eastern Japan in March 2011. Many survivors have been living in temporary houses provided by the local government since they lost their houses as a result of the great tsunami (tsunami group) or the expected high-dose radiation resulting from the nuclear accident at the Fukushima Daiichi Nuclear Power Plant (radiation group). The tsunami was more than 9 m high in Soma, Fukushima, which is located 30 km north of the Fukushima Daiichi Nuclear Power Plant and adjacent to the mandatory evacuation area. A health screening program was held for the evacuees in Soma in September 2011. The aim of this study was to compare the metabolic profiles of the evacuees before and after the disaster. We hypothesized that the evacuees would experience deteriorated metabolic status based on previous reports of natural disasters.Methods: Data on 200 subjects who attended a health screening program in September or October of 2010 (pre-quake) and 2011 (post-quake) were retrospectively reviewed and included in this study. Pre-quake and post-quake results of physical examinations and laboratory tests were compared in the tsunami and radiation groups. A multivariate regression model was used to determine pre-quake predictive factors for elevation of hemoglobin A1c (HbA1c) in the tsunami group.Results: Significantly higher values of body weight, body mass index, waist circumference, and HbA1c and lower high-density lipoprotein cholesterol levels were found at the post-quake screening when compared with the pre-quake levels (p = 0.004, p = 0.03, p = 0.008, p < 0.001, and p = 0.03, respectively). A significantly higher proportion of subjects in the tsunami group with high HbA1c, defined as >= 5.7%, was observed after the quake (34.3%) than before the quake (14.8%) (p < 0.001). Regional factors, periodic clinic visits, and waist circumference before the quake were identified as predictive factors on multivariate analysis for the deterioration of HbA1c.Conclusions: Post-quake metabolic variables were impaired compared with pre-quake baseline levels in survivors who were living in temporary houses. A natural disaster could affect metabolic profiles, and careful follow-up for survivors should be planned.