Apolipoprotein E isoform-specific reduction of extracellular amyloid in neuronal cultures
Apolipoprotein E isoform-specific reduction of extracellular amyloid in neuronal cultures
复制标题
DOI：
10.1016/s0169-328x(99)00073-x
复制
发表时间：
1999-05-07
期刊：
影响因子：
--
通讯作者：
Poirier, J
中科院分区：
文献类型：
--
作者：
Beffert, U;Aumont, N;Poirier, J
载脂蛋白E （apoE）和淀粉样肽都与阿尔茨海默病（AD）有关。利用初级海马神经元，我们证明apoE能够减少潜在毒性的细胞外淀粉样肽，可能是通过受体介导的机制。我们假设，apoE介导的淀粉样蛋白清除和细胞内积累的异构体特异性差异可能是apoE epsilon 4等位基因AD个体中观察到的淀粉样斑块数量增加的原因，至少部分原因。(C) 1999 Elsevier Science B.V.版权所有
Both apolipoprotein E (apoE) and amyloid peptides are associated with Alzheimer's disease (AD). Using primary hippocampal neurons, we demonstrate that apoE is capable of reducing potentially toxic extracellular amyloid peptides, likely through a receptor mediated mechanism. We hypothesize that isoform-specific differences in apoE-mediated amyloid clearance and intracellular accumulation may be responsible, at least in part, for the increased number of amyloid plaques observed in apoE epsilon 4 allele AD individuals. (C) 1999 Elsevier Science B.V. All rights reserved.