Hostility changes following antidepressant treatment: Relationship to stress and negative thinking
Hostility changes following antidepressant treatment: Relationship to stress and negative thinking
复制标题
DOI：
10.1016/s0022-3956(96)00034-9
复制
发表时间：
1996-11-01
影响因子：
4.8
通讯作者：
Rosenbaum, JF
中科院分区：
文献类型：
--
作者：
Fava, M;Davidson, K;Rosenbaum, JF
目前尚不清楚治疗后敌意的变化是否主要与抑郁症状的改善有关，或者也与消极思维或感知压力的减少密切相关。对94例门诊抑郁症患者在氟西汀治疗8周前后进行症状问卷（SQ）敌对量表、汉密尔顿抑郁量表（HAM-D）、认知问卷（CQ）和知觉压力量表（PSS）评定。我们观察到，与正常对照组相比，抑郁症患者在这些问卷上的得分显著升高。氟西汀治疗后，所有四份问卷的评分均出现统计学显著性降低。我们观察到SQ敌意的变化与抑郁严重程度和感知压力的变化显著正相关，在调整性别和基线SQ敌意后，这些关系仍然显着。SQ敌意变化和消极思维减少之间的关系只有在调整性别和基线SQ敌意后才变得显着。我们的研究结果表明，抗抑郁治疗后敌意的显着减少与抑郁症状，压力水平和消极思维的减少有关。版权所有（C）1996 Elsevier Science Ltd.
It is unclear whether changes in hostility following treatment are primarily related to improvement in depressive symptoms or are also closely associated with reductions in negative thinking or perceived stress. We evaluated 94 outpatients with major depression before and after eight weeks of fluoxetine treatment by administering the Symptom Questionnaire (SQ) Hostility Scale, the Hamilton Rating Scale for Depression (HAM-D), the Cognitions Questionnaire (CQ) and the Perceived Stress Scale (PSS). We observed significant elevations in scores on these questionnaires in depressed patients as compared to normal controls. Following treatment with fluoxetine, there was a statistically significant reduction in scores on all four questionnaires. We observed that changes in SQ Hostility were significantly positively related to changes in both depression severity and perceived stress, with these relationships remaining significant after adjusting for gender and baseline SQ Hostility. The relationship between SQ Hostility changes and reductions in negative thinking became significant only after adjusting for gender and baseline SQ hostility. Our results suggest that the marked decrease in hostility following antidepressant treatment is related to a reduction in depressive symptoms, stress levels and negative thinking. Copyright (C) 1996 Elsevier Science Ltd.