TH1 and TH2 lymphocyte development and regulation of TH cell-mediated immune responses of the skin
TH1 and TH2 lymphocyte development and regulation of TH cell-mediated immune responses of the skin
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DOI：
10.1111/j.1087-0024.2004.00829.x
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发表时间：
2004-01-01
影响因子：
--
通讯作者：
Carballido, JM
中科院分区：
文献类型：
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作者：
Biedermann, T;Röcken, M;Carballido, JM
自首次描述TH1和TH2细胞亚群以来，已经产生了对这些细胞作为两个极化和生理平衡亚群的发育和控制的见解。特别是，TH1-TH2概念对TH细胞介导的皮肤疾病的影响已经被发现。本文将综述控制TH1和TH2细胞发育的基本因素，如细胞因子IL-12和IL-4和转录因子，共刺激分子的可能作用，以及特化树突状细胞群。这些调节机制将在极化TH1或TH2皮肤疾病如牛皮癣和特应性皮炎的背景下讨论。还介绍了控制趋化因子和趋化因子受体如何将TH1和TH2细胞招募到炎症部位以及它们如何放大这些极化的TH细胞反应的原理。所有这些概念，包括il -4诱导TH1反应的新作用，可以有助于设计更好的治疗策略来调节TH细胞介导的免疫反应。
Since the first description of the subpopulations of TH1 and TH2 cells, insights into the development and control of these cells as two polarized and physiologically balanced subsets have been generated. In particular, implications of the TH1-TH2 concept for TH cell-mediated skin disorders have been discovered. This article will review the basic factors that control the development of TH1 and TH2 cells, such as the cytokines IL-12 and IL-4 and transcription factors, the possible role of costimulatory molecules, and specialized dendritic cell populations. These regulatory mechanisms will be discussed in the context of polarized TH1 or TH2 skin disorders such as psoriasis and atopic dermatitis. Also presented are the principles that govern how chemokines and chemokine receptors recruit TH1 and TH2 cells to inflammatory sites and how they amplify these polarized TH cell responses. All of these concepts, including a novel role for IL-4-inducing TH1 responses, can contribute to the design of better therapeutic strategies to modulate TH cell-mediated immune responses.