Myocardial layer-specific analysis in patients with heterozygous familial hypercholesterolemia using speckle tracking echocardiography
Myocardial layer-specific analysis in patients with heterozygous familial hypercholesterolemia using speckle tracking echocardiography
复制标题
使用斑点追踪超声心动图对杂合子家族性高胆固醇血症患者进行心肌层特异性分析
DOI：
10.1111/echo.13442
复制
发表时间：
2017-03-01
影响因子：
1.5
通讯作者：
Yang, Ya
中科院分区：
文献类型：
--
作者：
Leng, Zhaoting;Li, Rongjuan;Yang, Ya
目的：家族性高胆固醇血症（Familial hypercholesterol - olemia， FH）是一种最常见、最严重的单基因脂质代谢疾病，从出生起因动脉粥样硬化加速而导致过早的冠心病（CHD），对该病左室功能的研究较少。本研究旨在探讨层特异性应变在无症状和左室射血分数（LVEF）保存完好的杂合性FH （HeFH）患者早期左室功能损害评估中的价值。方法：选取2010 - 2016年经胸超声心动图诊断为杂合型家族性高胆固醇血症的患者49例，年龄38.7 +/- 8.7岁。选取年龄35.6 +/- 10.3岁的健康志愿者32名作为对照组。通过软件获得心内膜、心肌和心外膜（LSendo、LSmyo、LSepi和CSendo、CSmyo、CSepi）的纵向和周向应变，可以分析三个心肌层的应变。结果：在纵应变（LS）方面，HeFH患者的心内膜LS （LSendo）和心肌LS （LSmyo）均明显降低
Objective: Familial hypercholesterolemia (FH) is the most common and serious monogenic disorder of lipid metabolism, causing premature coronary heart disease (CHD) due to accelerated atherosclerosis from birth, and the study of left ventricular (LV) function of this disease is seldom. The purpose of this study was to explore the value of layer-specific strain on assessing the early damage of LV function in asymptomatic and left ventricular ejection fraction (LVEF) well-preserved patients with heterozygous FH (HeFH).Methods: A total of 49 patients aged 38.7 +/- 8.7 diagnosed with heterozygous familial hypercholesterolemia and who had undergone transthoracic echocardiography from 2010 to 2016 were included in this study. A total 32 healthy volunteers aged 35.6 +/- 10.3 were included as control group. Longitudinal and circumferential strains of the endocardium, myocardium, and epicardium (LSendo, LSmyo, and LSepi and CSendo, CSmyo, and CSepi) were obtained by a software enabling the analysis of strains in three myocardial layers.Results: In longitudinal strain (LS), the LS of endocardium (LSendo) and the LS of myocardium (LSmyo) are significantly reduced in patients with HeFH (P