Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models
Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models
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DOI：
10.1080/22221751.2019.1637072
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发表时间：
2019-07-25
影响因子：
13.2
通讯作者：
Hu, Jiafen
中科院分区：
文献类型：
--
作者：
Cladel, Nancy M.;Jiang, Pengfei;Hu, Jiafen
人类乳头瘤病毒(HPV)导致大多数宫颈癌，并被认为是性传播的。然而，乳头瘤病毒经常在包括胃在内的内脏癌症中发现，这引发了病毒如何进入这些部位的问题。输血和HPV相关疾病之间可能的联系还没有得到太多关注。在这里，我们展示了在兔和小鼠模型中，感染乳头瘤病毒的血液在可检测到病毒DNA、RNA转录本和蛋白质产物的允许部位产生感染。血液感染诱导的兔皮肤肿瘤与局部感染诱导的肿瘤一样，SLN、Tac1、MYH8、PGAM2和APOBEC2表达降低，SDRC7、KRT16、S100A9、IL36G和FABP9表达增强。此外，我们还证明了来自受感染小鼠的血液可以将感染传播给未受感染的动物。最后，我们证明了通过血液感染的动物的胃组织中存在乳头瘤病毒感染和病毒诱导的增殖。这些结果表明，血液传播可能是乳头瘤病毒感染的另一种途径，这意味着没有对乳头瘤病毒进行筛查的人类血液供应可能是HPV感染以及随后与病毒无关的组织中癌症的潜在来源。
Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how the viruses gain access to these sites. A possible connection between blood transfusion and HPV-associated disease has not received much attention. Here we show, in rabbit and mouse models, that blood infected with papillomavirus yields infections at permissive sites with detectable viral DNA, RNA transcripts, and protein products. The rabbit skin tumours induced via blood infection displayed decreased expression of SLN, TAC1, MYH8, PGAM2, and APOBEC2 and increased expression of SDRC7, KRT16, S100A9, IL36G, and FABP9, as seen in tumours induced by local infections. Furthermore, we demonstrate that blood from infected mice can transmit the infection to uninfected animals. Finally, we demonstrate the presence of papillomavirus infections and virus-induced hyperplasia in the stomach tissues of animals infected via the blood. These results indicate that blood transmission could be another route for papillomavirus infection, implying that the human blood supply, which is not screened for papillomaviruses, could be a potential source of HPV infection as well as subsequent cancers in tissues not normally associated with the viruses.