CCR7 directs the migration of thymocytes into the thymic medulla
CCR7 directs the migration of thymocytes into the thymic medulla
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DOI：
10.4049/jimmunol.172.7.3999
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发表时间：
2004-04-01
影响因子：
4.4
通讯作者：
Killeen, N
中科院分区：
文献类型：
--
作者：
Kwan, J;Killeen, N
发育中的胸腺细胞在正选择的作用下从胸腺皮质迁移到髓质。这种迁移对于耐受性可能是必不可少的，因为它允许发育中的细胞进入最适合负选择的环境。将阳性选择的胸腺细胞吸引到髓质的引导机制尚未阐明，但一些研究表明趋化因子参与了该过程。CCR7是髓质趋化因子CCL19和CCL21的受体，在胸腺细胞的阳性选择过程中被诱导。在这项研究中，我们发现CCR7的过早表达将CD4（+）CD8（+）双阳性细胞重新定位到转基因小鼠的髓质中。胸腺细胞的这种重新定位伴随着其发育的损害。这些数据显示了CCR7参与髓质迁移，并强调了胸腺细胞适当定位对有效T细胞发育的重要性。
Developing thymocytes migrate from the cortex to the medulla of the thymus as a consequence of positive selection. This migration is likely to be essential for tolerance because it allows the developing cells to move into an environment that is optimal for negative selection. Guidance mechanisms that draw positively selected thymocytes into the medulla have not been clarified, but several studies have implicated chemokines in the process. CCR7, the receptor for the medullary chemokines CCL19 and CCL21, is induced on thymocytes during their positive selection. In this study we show that premature expression of CCR7 repositions CD4(+)CD8(+) double-positive cells into the medulla of transgenic mice. This repositioning of the thymocytes is accompanied by impairment of their development. The data show the involvement of CCR7 in medullary migration and emphasize the importance of proper thymocyte positioning for efficient T cell development.