EARLY-ONSET MAJOR DEPRESSION IN PARENTS AND THEIR CHILDREN
EARLY-ONSET MAJOR DEPRESSION IN PARENTS AND THEIR CHILDREN
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DOI：
10.1016/0165-0327(88)90024-9
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发表时间：
1988-11-01
影响因子：
6.6
通讯作者：
PRUSOFF, BA
中科院分区：
文献类型：
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作者：
WEISSMAN, MM;WARNER, V;PRUSOFF, BA
在一项针对6-23岁的抑郁症和正常父母的子女的研究中，发现子女的重度抑郁症发病率与先证者父母的重度抑郁症发病年龄呈反比关系，父母的重度抑郁症发病年龄总体上小于20岁的子女患重度抑郁症的风险最高。研究结果的特异性在于，这些较高的发病率几乎都是由他们的孩子在青春期前出现重度抑郁症引起的。在20岁以下发病的先证者的孩子中，13岁之前发病的风险增加了14倍。这些结果不受先证者或子女的当前年龄、访谈状态（子女接受访谈）、父母的共病或强迫性交配的混淆。未来的家族遗传学研究应该检查青春期前发病的重性抑郁症先证者的生物学亲属的患病率和模式。
In a study of 6-23-year-old offspring of depressed and of normal parents, an inverse relationship between the rates of major depression among the children and the age of onset of major depression in their proband parents was found. The children of parents who had an onset of major depression that was younger than age 20 years overall had the highest risk of major depression. There was specificity in the findings in that these higher rates were nearly all accounted for by prepubertal onsets of major depression in their children. There was a 14-fold increased risk of onset of depression before age 13 in the children of probands who had onset less than age 20. These results were not confounded by the current age of the proband or the children, by interview status (children were interviewed), by comorbidity in the parents or by assortative mating. Future family genetic studies should examine the rates and patterns of illness of the biological relatives of probands with prepubertal-onset major depression.