Martrilin-3 (MATN3) Overexpression in Gastric Adenocarcinoma and its Prognostic Significance.
Martrilin-3 (MATN3) Overexpression in Gastric Adenocarcinoma and its Prognostic Significance.
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Martrilin-3 (MATN3) 在胃腺癌中的过度表达及其预后意义
DOI：
10.12659/msm.908447
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发表时间：
2018-01-18
期刊：
影响因子：
--
通讯作者：
Hu B
中科院分区：
文献类型：
--
作者：
Wu PL;He YF;Yao HH;Hu B
本研究的目的是探讨胃癌组织中martrilin-3（MATN 3）的表达水平及其与胃癌预后的关系。材料/方法应用基因表达谱（GEO）和癌症基因组图谱（TCGA）数据预测GAC患者中MATN 3 mRNA的表达及其预后价值。回顾性收集76例GAC患者的GAC组织样本和配对的邻近正常组织样本，通过免疫组织化学染色检测MATN 3蛋白表达水平。Kaplan-Meier单因素和考克斯多因素分析验证MATN 3表达与GAC患者临床病理参数的相关性及其预后意义。结果GEO和TCGA数据预测GAC组织中MATN 3 mRNA水平显著高于正常组织（均p<0.05）。进一步的生存分析显示，MATN 3 mRNA高表达的GAC患者的无病生存期（DFS）和总生存期（OS）时间显著低于MATN 3 mRNA低表达的患者（均p<0.05）。随后的免疫组织化学染色结果证实，与正常组织相比，GAC组织中的MATN 3蛋白水平高度表达（p=0.000）。此外，与MATN 3蛋白低表达的患者相比，MATN 3蛋白高表达的GAC患者的OS显著降低（p=0.000）。单变量和多变量生存分析显示，MATN 3高表达可作为GAC患者预后不良的独立预测因子（所有p=0.000）。结论MATN 3蛋白在GAC患者中呈高表达，MATN 3蛋白过表达可作为GAC患者预后不良的独立预测因子。
Background The aim of this study was to investigate the expression level of martrilin-3 (MATN3) in patients with gastric adenocarcinoma (GAC) and to investigate the prognostic significance of MATN3. Material/Methods Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) data were used to predict the expression and prognostic value of MATN3 mRNA in GAC patients. Seventy-six GAC patients had GAC tissue samples and paired adjacent normal tissue samples collected retrospectively to examine the MATN3 protein expression level by immunohistochemical staining. Furthermore, Kaplan-Meier univariate and Cox multivariate analyses were used to verify the correlation between MATN3 expression and clinicopathological parameters of GAC patients and the prognostic significance of MATN3. Results The GEO and TCGA data predicted that MATN3 mRNA levels were significantly higher in GAC tissue compared to normal tissue (all p<0.05). Further survival analyses showed that GAC patients with high mRNA expression of MATN3 had significantly lower disease-free survival (DFS) and overall survival (OS) time than those with low mRNA expression of MATN3 (all p<0.05). Subsequent immunohistochemical staining results confirmed that the MATN3 protein levels in GAC tissues were highly expressed (p=0.000) compared to normal tissues. In addition, GAC patients with high protein expression of MATN3 had remarkably decreased OS compared to patients with low protein expression of MATN3 (p=0.000). Univariate and multivariate survival analyses revealed that MATN3 high expression could be used as an independent predictor of poor prognosis in GAC patients (all p=0.000). Conclusions This study confirmed that MATN3 protein was highly expressed in GAC patients, and MATN3 overexpression could be used as an independent predictor of poor prognosis in GAC patients.
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