Evaluation of contributors to amide proton transfer-weighted imaging and nuclear Overhauser enhancement-weighted imaging contrast in tumors at a high magnetic field.
Evaluation of contributors to amide proton transfer-weighted imaging and nuclear Overhauser enhancement-weighted imaging contrast in tumors at a high magnetic field.
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DOI：
10.1002/mrm.29675
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发表时间：
2023-08
影响因子：
3.3
通讯作者：
Zu, Zhongliang
中科院分区：
文献类型：
--
作者：
Cui, Jing;Zhao, Yu;Sun, Casey;Xu, Junzhong;Zu, Zhongliang
关键词：
目的是评价混杂因素(T1w和MT)对定量的APT和NOE(−3.5)的化学交换饱和转移比(CESTR)的相对贡献，以及CESTR是否能反映溶质浓度(F)的分布。我们首先提供了一个信号模型，该模型显示了CESTR对这些混杂因素的独立依赖性，以及由表观交换依赖松弛(AREX)方法量化的干净的CEST/NOE效应。然后，我们在大鼠的9L肿瘤模型中测量了这些效应的变化，通过这些变化，我们计算了每个混杂因素的相对贡献。对FS进行拟合，并与CESTR和AREX进行相关分析，以评价其反映FS的能力。CESTR定量的APT在肿瘤中显示“阳性”对比，在低功率时主要来自R1w，在高功率时主要来自R1w和MT。CESTR定量的NOE(−3.5)在肿瘤中显示无对比度或弱对比度，这是由于R1w和NOE(−3.5)的相反贡献被取消所致。CESTR定量的APT与APT FS的相关性比AREX定量的APT更强。CESTR量化的NOE(−3.5)与NOE(−3.5)的相关性弱于−量化的NOE(AREX 3.5)。CESTR反映了T1w和CEST/NOE的综合作用。这两个因素都依赖于FS，这对APT成像中CESTR对FS的依赖性有积极作用，并增强了CESTR与FS的相关性。相反，在NOE(−3.5)成像中，这些因素对它对f的依赖性有相反的贡献，从而削弱了相关性。
The purpose is to evaluate the relative contribution from confounding factors (T1w and MT) to the chemical exchange saturation transfer ratio (CESTR) quantified APT and NOE(−3.5) in tumors as well as whether the CESTR can reflect the distribution of the solute concentration (fs). We first provided a signal model that shows the separate dependence of CESTR on these confounding factors and the clean CEST/NOE effects quantified by an apparent exchange-dependent relaxation (AREX) method. We then measured the change in these effects in the 9L tumor model in rats, through which we calculated the relative contribution of each confounding factor. fs was also fitted, and its correlations with the CESTR and AREX was assessed to evaluate their capabilities to reflect fs. The CESTR-quantified APT shows ‘positive’ contrast in tumors, which mainly arises from R1w at low powers and both R1w and MT at high powers. CESTR-quantified NOE(−3.5) shows no or weak contrast in tumors, which is due to the cancellation of R1w and NOE(−3.5) which have opposite contributions. CESTR-quantified APT has a stronger correlation with APT fs than AREX-quantified APT. CESTR-quantified NOE(−3.5) has a weaker correlation with NOE(−3.5) fs than AREX-quantified NOE(−3.5). CESTR reflects a combined effect of T1w and CEST/NOE. Both of these factors depend on fs, which contributes positively to the dependence of CESTR on fs in APT imaging and enhances its correlation with fs. In contrast, these factors have opposite contributions to its dependence on fs in NOE(−3.5) imaging, thereby weakening the correlation.
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DOI：
10.1158/1078-0432.ccr-18-1233
发表时间：
2019-01-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Jiang S;Eberhart CG;Lim M;Heo HY;Zhang Y;Blair L;Wen Z;Holdhoff M;Lin D;Huang P;Qin H;Quinones-Hinojosa A;Weingart JD;Barker PB;Pomper MG;Laterra J;van Zijl PCM;Blakeley JO;Zhou J
通讯作者：
Zhou J
影响因子：
3.4
作者：
O'Grady KP;Satish S;Owen QR;Box BA;Bagnato F;Combes AJE;Cook SR;Westervelt HJ;Feiler HR;Lawless RD;Sarma A;Malone SD;Ndolo JM;Yoon K;Dortch RD;Rogers BP;Smith SA
通讯作者：
Smith SA
影响因子：
3.3
作者：
Cui J;Zhao Y;Wang F;Gochberg DF;Zu Z
通讯作者：
Zu Z
影响因子：
2.9
作者：
通讯作者：
--
影响因子：
3.3
作者：
Desmond, Kimberly L.;Moosvi, Firas;Stanisz, Greg J.
通讯作者：
Stanisz, Greg J.