Anti-inflammatory Cyathane Diterpenoids from Sarcodon scabrosus
Anti-inflammatory Cyathane Diterpenoids from Sarcodon scabrosus
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DOI：
10.1271/bbb.68.1362
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发表时间：
2004-01
期刊：
影响因子：
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通讯作者：
T. Kamo;Y. Imura;Tomomi Hagio;H. Makabe;H. Shibata;M. Hirota
中科院分区：
文献类型：
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作者：
T. Kamo;Y. Imura;Tomomi Hagio;H. Makabe;H. Shibata;M. Hirota
从粗肉齿菌Sarcodon scabrosus（Fr.）喀斯特（紫草科）与奈氏codonin A.其中一个新化合物经光谱分析鉴定为杯形二萜类化合物，即奈氏可多宁O。经与合成的真实样品比较，其他化合物被鉴定为sarcodonin A的19-O-亚油酰基、19-O-油酰基和19-O-硬脂酰基衍生物。这些化合物，连同从sarcodonin A合成的五个19-O-酰基衍生物，通过局部应用，每个都表现出对12-O-十四酰基佛波醇-13-乙酸酯（TPA）诱导的小鼠耳炎症的抑制活性。
Four novel diterpenoids were isolated from the fruiting bodies of Sarcodon scabrosus (Fr.) Karst. (Boraginaceae) together with neosarcodonin A. One of the novel compounds was elucidated to be a cyathane diterpenoid, namely neosarcodonin O, by its spectral data. The others were characterized as 19-O-linoleoyl, 19-O-oleoyl and 19-O-stearoyl derivatives of sarcodonin A, after comparison with the authentic samples synthetically prepared from sarcodonin A. These compounds, together with the five 19-O-acyl derivatives synthesized from sarcodonin A, each exhibited inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation on mouse ears by topical application.