A SAUVAGINE CORTICOTROPIN-RELEASING FACTOR-RECEPTOR EXPRESSED IN HEART AND SKELETAL-MUSCLE
A SAUVAGINE CORTICOTROPIN-RELEASING FACTOR-RECEPTOR EXPRESSED IN HEART AND SKELETAL-MUSCLE
复制标题
DOI：
10.1073/pnas.92.4.1108
复制
发表时间：
1995-02-14
影响因子：
11.1
通讯作者：
ROSENFELD, MG
中科院分区：
文献类型：
--
作者：
KISHIMOTO, T;PEARSE, RV;ROSENFELD, MG
促肾上腺皮质激素释放因子 (CRF) 介导应激生理反应的许多关键方面。这些效应是通过与特定的高亲和力受体结合而引起的，这些受体与鸟嘌呤核苷酸刺激因子 (G(s)) 反应途径偶联。最近，分离并鉴定了在垂体和中枢神经系统中表达的编码 CRF 受体（PC-CRF 受体）的基因。在此，我们报告了第二种不同的 CRF 受体的鉴定和表征，该受体主要在心脏和骨骼肌中表达，与 PC-CRF 受体相比，表现出特定的配体偏好和拮抗剂敏感性。我们将第二种受体称为心脏/肌肉 (HM)-CRF 受体。
Corticotropin-releasing factor (CRF) mediates many critical aspects of the physiological response to stress. These effects are elicited by binding to specific high-affinity receptors, which are coupled to guanine nucleotide stimulatory factor (G(s))-response pathways. Recently, a gene encoding a receptor for CRF, expressed in pituitary and the central nervous system (PC-CRF receptor), was isolated and characterized. Here we report the identification and characterization of a second, distinct CRF receptor that is expressed primarily in heart and skeletal muscle and exhibits a specific ligand preference and antagonist sensitivity compared with the PC-CRF receptor. We refer to this second receptor as the heart/muscle (HM)-CRF receptor.