Urocortin 1: A putative excitatory neurotransmitter in the enteric nervous system
Urocortin 1: A putative excitatory neurotransmitter in the enteric nervous system
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DOI：
10.1111/nmo.13842
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发表时间：
2020-03
影响因子：
3.5
通讯作者：
S. Yamato;A. Kurematsu;T. Amano;H. Ariga;T. Ando;G. Komaki;K. Wada
中科院分区：
文献类型：
--
作者：
S. Yamato;A. Kurematsu;T. Amano;H. Ariga;T. Ando;G. Komaki;K. Wada
尿皮质素1（Ucn1）是一种应激相关肽，是促肾上腺皮质激素释放因子（CRF）家族的成员，并作为CRF 1受体激动剂。Ucn 1和CRF 1受体免疫反应性存在于肠神经系统（ENS）中，并且Ucn 1引起结肠肌条的收缩。考虑到这些研究结果，我们假设Ucn 1作为一种兴奋性神经递质在ENS。本研究进行，以确定是否外源性应用Ucn 1引起收缩，它是否参与神经介导的收缩，以及它是否被释放从ENS的大鼠结肠。
Urocortin 1 (Ucn1), a stress‐related peptide, is a member of the corticotropin‐releasing factor (CRF) family and acts as a CRF1 receptor agonist. Ucn1 and CRF1 receptor immunoreactivity are present in the enteric nervous system (ENS), and Ucn1 elicits contraction of colonic muscle strips. Considering these findings, we have hypothesized that Ucn1 acts as an excitatory neurotransmitter in the ENS. The present study was conducted to determine whether exogenously applied Ucn1 causes contractions, whether it participates in neurally mediated contraction, and whether it is released from the ENS of the rat colon.