The developmental origins of adult disease
The developmental origins of adult disease
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DOI：
10.1080/07315724.2004.10719428
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发表时间：
2004-12-01
影响因子：
3.5
通讯作者：
Barker, DJP
中科院分区：
文献类型：
--
作者：
Barker, DJP
现在已知低出生体重与冠心病以及相关疾病（中风、高血压和非胰岛素依赖型糖尿病）的发病率升高有关。这些关联在不同国家的研究中已被广泛重复验证，并非混杂变量所致。它们涵盖了出生体重的正常范围，并且取决于相对于妊娠期而言较低的出生体重，而非早产的影响。这些关联被认为是发育可塑性的结果，发育可塑性是指一种基因型在发育过程中可因应不同的环境条件而产生一系列不同的生理或形态状态的现象。近期的观察表明，婴儿期生长不良以及儿童期体重快速增加会加剧产前生长不良的影响。一种兼顾短期和长期结果的最佳人类早期发育的新观点正在形成。
Low birthweight is now known to be associated with increased rates of coronary heart disease and the related disorders stroke, hypertension and non-insulin dependent diabetes. These associations have been extensively replicated in studies in different countries and are not the result of confounding variables. They extend across the normal range of birthweight and depend on lower birthweights in relation to the duration of gestation rather than the effects of premature birth. The associations are thought to be consequences of developmental plasticity, the phenomenon by which one genotype can give rise to a range of different physiological or morphological states in response to different environmental conditions during development. Recent observations have shown that impaired growth in infancy and rapid childhood weight gain exacerbate the effects of impaired prenatal growth. A new vision of optimal early human development is emerging which takes account of both short and long-term outcomes.