Sleep-related breathing disorder is an independent risk factor for systemic hypertension
Sleep-related breathing disorder is an independent risk factor for systemic hypertension
复制标题
DOI：
10.1164/ajrccm.160.6.9811054
复制
发表时间：
1999-12-01
影响因子：
24.7
通讯作者：
Peter, JH
中科院分区：
文献类型：
--
作者：
Grote, L;Ploch, T;Peter, JH
睡眠呼吸障碍(SRBD)对血压控制的确切影响尚不清楚。我们调查了1190名连续诊断为SRBD的患者，调查了不同程度的SRBD对白天血压的影响及其与记录的高血压的关系。协议包括临床访谈、体检、办公室血压测量、胆固醇和血气分析。无人值守的家庭夜间呼吸监测用于评估SRBD的活动(呼吸紊乱指数[RDI])。RDI值与安静时的收缩压(非标准化系数[B]=0.07+/-0.03，p=0.03)、舒张压(B=0.07+/-0.02，p=0.001)和心率(B=0.10+/-0.02p&t；0.001)独立且线性相关。高血压(血压160/95 mm Hg)的相对风险随着SRBD严重程度的增加而增加(RDI大于或等于40的优势比[OR]为4.15 vs<；5[95%CI，2.7至6.5])。与年龄较大的患者(50岁)相比，年轻患者(小于或等于50岁)的相对风险也较高(RDIa40与RDIA5的OR值分别为7.15和2.70)。这些横断面临床数据表明，在控制了体重指数(BMI)、年龄、酒精/尼古丁消耗量、胆固醇水平以及日间Po-2和PCO(2)等混杂因素后，SRBD的严重程度与收缩压、舒张压和心率之间存在关系。SRBD是系统性高血压的独立危险因素，在小于或等于50岁的受试者中，其可能性增加。
The exact influence of sleep-related breathing disorder (SRBD) on blood pressure control remains unknown. We investigated the influence of different degrees of SRBD on daytime blood pressure and its association to documented hypertension by examining 1,190 consecutive patients referred for diagnosis of SRBD. The protocol includes clinical interview, physical examination, office blood pressure measurement, cholesterol, and blood gas analysis. Unattended home monitoring of nocturnal breathing was performed for assessment of SRBD activity (respiratory disturbance index [RDI]). RDI was independently and linearly associated with systolic blood pressure (unstandardized coefficient [B] = 0.07 +/- 0.03, p = 0.03), diastolic blood pressure (B = 0.07 +/- 0.02, p = 0 < 0.001), and heart rate (B = 0.10 +/- 0.02 p < 0.001) at rest. The relative risk for hypertension (blood pressure a 160/95 mm Hg) increased with SRBD severity (odds ratio [OR], 4.15 for RDI greater than or equal to 40 versus < 5 [95% CI, 2.7 to 6.5]). This relative risk was also elevated in younger (less than or equal to 50 yr) compared with older patients (> 50 yr) (OR, 7.15 versus 2.70 for RDI a 40 versus < 5). These cross-sectional clinical data suggest a relationship between SRBD severity and systolic blood pressure, diastolic blood pressure, and heart rate after control for confounders such as body mass index (BMI), age, alcohol/nicotine consumption, cholesterol level, and daytime Po-2 and Pco(2). SRBD is an independent risk factor for systemic hypertension with an increased likelihood in subjects less than or equal to 50 yr of age.