The effect of chronic clonidine administration on salivary glands and caries in the rat.
The effect of chronic clonidine administration on salivary glands and caries in the rat.
复制标题
长期服用可乐定对大鼠唾液腺和龋齿的影响。
DOI：
10.1159/000016589
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发表时间：
2000
期刊：
影响因子：
4.2
通讯作者：
Bowen,WH
中科院分区：
文献类型：
--
作者：
Watson,GE;Pearson,SK;Bowen,WH
可乐定是一种广泛使用的中枢降压药，其药理机制是刺激中枢突触后α2 -肾上腺素能受体和突触前α2 -肾上腺素能受体的激动剂活性，干扰外周去甲肾上腺素和乙酰胆碱释放的调节。这两种机制都可能对唾液分泌和组成产生不利影响，潜在地增加个体患龋的风险。本研究的目的是确定长期服用可乐定对大鼠唾液、唾液腺和龋齿的影响。Sprague-Dawley大鼠幼崽感染了sobrincoccus，给予2000日粮和10%的蔗糖水，并进行去盐处理，或用盐酸可乐定（125或250 μg/kg，通过渗透微型泵每天给药，连续28天），或作为对照组。两组患者受刺激的腮腺、颌下腺唾液分泌量和舌下腺重量均无统计学差异。与对照组相比，接受可乐定治疗的动物的下颌下腺重量占总体重的百分比显著降低。与对照组相比，可乐定组和高可乐定组的龈沟龋齿评分和光滑表面龋齿评分均有所增加。阳性对照动物（去盐）的龋齿评分明显高于其他所有组。这些数据表明，长期服用可乐定可显著降低颌下腺的重量，增加龋齿的易感性。
Clonidine is a widely prescribed, centrally acting antihypertensive with proposed pharmacologic mechanisms of stimulation of central postsynaptic α2–adrenergic receptors and agonist activity at presynaptic α2–adrenergic receptors, interfering with peripheral regulation of norepinephrine and acetylcholine release. Both of these mechanisms are capable of adversely influencing salivary output and composition, potentially leaving an individual with increased caries risk. The purpose of the present study was to determine the effect of chronic administration of clonidine on saliva, salivary glands, and caries in rats. Sprague–Dawley rat pups were infected withStreptococcus sobrinus, given Diet 2000 and 10% sucrose water ad libitum, and either desalivated, or treated with clonidine HCl (125 or 250 μg/kg administered daily for 28 days by means of osmotic minipumps), or assigned as controls. There were no statistical differences in stimulated parotid or submandibular gland salivary output or sublingual gland weights among the groups. The weight of the submandibular glands as a percent of total body weight was significantly decreased in animals that received clonidine when compared with controls. Sulcal caries scores in both clonidine groups and smooth surface caries scores in the high clonidine group were increased when compared with control animals. Positive control animals (desalivated) had significantly higher caries scores than all other groups. These data show that chronic administration of clonidine significantly decreases submandibular gland weight and increases susceptibility to dental caries.