Orienting attention in time:: behavioural and neuroanatomical distinction between exogenous and endogenous shifts
Orienting attention in time:: behavioural and neuroanatomical distinction between exogenous and endogenous shifts
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DOI：
10.1016/s0028-3932(99)00132-3
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发表时间：
2000-01-01
期刊：
影响因子：
2.6
通讯作者：
Nobre, AC
中科院分区：
文献类型：
--
作者：
Coull, JT;Frith, CD;Nobre, AC
注意力的时间定向是在特定时刻集中资源以优化行为的能力，并且与左顶叶和前运动皮层的激活相关[Coull，J.T.，诺布雷A. C.何时何地需要注意。正电子发射断层扫描（PET）和功能性磁共振成像（fMRI）显示的将注意力引导到空间位置和时间间隔的神经系统。Journal of Neuroscience，1998，18，7426 7435].在本实验中，我们探讨了行为和解剖学相关的时间定向中央凹视觉刺激，以消除任何空间注意混淆。我们实施了一个双向析因设计的事件相关的功能磁共振成像研究，以检查试验效度的因素（线索的目标的可预测性），延迟的长度（线索-目标间隔），以及它们之间的相互作用。有两种不同类型的无效试验：那些注意力被自动吸引到一个过早的目标和那些注意力被自愿转移到一个延迟的时间点。有效的试验的反应时间短于无效的试验，表现出适当的时间线索的注意力分配。所有的试验类型激活了一个共享的系统，包括额顶叶区双边，这表明该网络始终与注意力定向，并不是特定的空间任务。不同的大脑区域对线索目标延迟和试验有效性敏感。长的线索-目标间隔激活了参与运动准备的区域：辅助运动皮层、基底神经节和丘脑。无效的试验，在时间的预期被打破，显示增强激活左顶叶和额叶区，并参与眶额皮质双边。最后，审判效度与延迟的长度相互作用。提前出现目标选择性激活视纹外皮层，而推迟出现目标选择性激活右前额叶皮层。这些研究结果表明，不同的布兰地区参与重新定向注意力的基础上的感觉事件（自下而上，外源性的转变）和认知预期（自上而下，内源性的转变）。(C)2000爱思唯尔科技有限公司版权所有。
Temporal orienting of attention is the ability to focus resources at a particular moment in time in order to optimise behaviour, and is associated with activation of left parietal and premotor cortex [Coull, J. T., Nobre. A. C. Where and when to pay attention. the neural systems for directing attention to spatial locations and to time intervals as revealed by both PET and fMRI. Journal of Neuroscience, 1998, 18, 7426 7435]. In the present experiment, wee explored the behavioural and anatomical correlates of temporal orienting to foveal visual stimuli, in order to eliminate any spatial attention confounds. We implemented a two-way factorial design in an event-related fMRI study to examine the factors of trial validity (predictability of target by cue), length of delay (cue-target interval), and their interaction. There were two distinct types of invalid trial: those where attention was automatically drawn to a premature target and those where attention was voluntarily shifted to a delayed time-point. Reaction times for valid trials were shorter than those for invalid trials, demonstrating appropriate allocation of attention to temporal cues. All trial-types activated a shared system, including frontoparietal areas bilaterally, showing that this network is consistently associated with attentional orienting and is not specific to spatial tasks. Distinct brain areas were sensitive to cue target delays and to trial validity. Long cue-target intervals activated areas involved in motor preparation: supplementary motor cortex, basal ganglia and thalamus. Invalid trials, where temporal expectancies were breached, showed enhanced activation of left parietal and frontal areas, and engagement of orbitofrontal cortex bilaterally. Finally, trial validity interacted with length of delay. Appearance of targets prematurely selectively activated visual extrastriate cortex; while postponement of target appearance selectively activated right prefrontal cortex. These findings suggest that distinct blain areas are involved in redirecting attention based upon sensory events (bottom-up, exogenous shifts) and based upon cognitive expectations (top-down, endogenous shifts). (C) 2000 Elsevier Science Ltd. All rights reserved.