Indocyanine green-loaded photoacoustic nanodroplets: dual contrast nanoconstructs for enhanced photoacoustic and ultrasound imaging.
Indocyanine green-loaded photoacoustic nanodroplets: dual contrast nanoconstructs for enhanced photoacoustic and ultrasound imaging.
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DOI：
10.1021/nn403527r
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发表时间：
2014-01-28
期刊：
影响因子：
17.1
通讯作者：
Emelianov S
中科院分区：
文献类型：
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作者：
Hannah A;Luke G;Wilson K;Homan K;Emelianov S
最近，将全氟化合物（PFC）纳米光子作为成像和图像引导治疗的对比剂引入。例如，在超声检查中，高强度超声脉冲用于相变液体全氟化合物以产生气体微泡。最近，将具有包裹金纳米棒的全氟碳纳米体用作双超声/光声对比剂。为了加快临床翻译，我们合成并表征了由ICG负载的全氟纳米核，即包括生物相容性，无毒和生物学安全材料的结构。然后，我们通过PFC纳米光的光学相变和所得PFC气泡的超声对比，证明了光声对比度增强。我们通过分析对比度和对比度比率评估了光声和超声图像的质量增强。我们进一步研究了由于环境温度升高而导致的图像对比度变化。我们的研究表明，载有ICG的全氟碳纳米光子可能成为各种成像方式的宝贵工具，并具有有希望的治疗应用。
Recently, perfluorocarbon (PFC) nanodroplets were introduced as contrast agents for imaging and image-guided therapy. For example, in sonography, high-intensity ultrasound pulses were used to phase-transition liquid perfluorocarbon to produce gas microbubbles. More recently, perfluorocarbon nanodroplets with encapsulated gold nanorods were used as dual ultrasound/photoacoustic contrast agents. To expedite clinical translation, we synthesized and characterized ICG-loaded perfluorocarbon nanodroplets, i.e. constructs comprising biocompatible, non-toxic and biologically safe materials. We then demonstrated enhanced photoacoustic contrast through optically triggered phase transition of PFC nanodroplets and ultrasound contrast from the resulting PFC bubbles. We assessed the quality enhancement of photoacoustic and ultrasound images through analysis of contrast and contrast-to-noise ratio. We further investigated the changes in image contrast due to increased ambient temperature. Our studies suggest that ICG-loaded perfluorocarbon nanodroplets may become a valuable tool for various imaging modalities, and have promising therapeutic applications.