Prognostic factors in patients with advanced biliary tract cancer receiving chemotherapy
Prognostic factors in patients with advanced biliary tract cancer receiving chemotherapy
复制标题
DOI：
10.1007/s00280-010-1360-7
复制
发表时间：
2011-04-01
影响因子：
3
通讯作者：
Koike, Kazuhiko
中科院分区：
文献类型：
--
作者：
Sasaki, Takashi;Isayama, Hiroyuki;Koike, Kazuhiko
晚期胆道癌患者接受化疗的预后因素目前还没有很好的确定。胆囊癌和肝内胆管癌是以前报道的预后不良的预后因素，但是，肿瘤体积还没有在这些以前的reports.We分析了56例连续晚期胆道癌谁接受吉西他滨和S-1联合化疗作为一线姑息化疗。采用实体瘤疗效评价标准中肿瘤体积的基线最长直径之和（BSLD）作为影响预后的因素，多因素分析结果显示，年龄a千分之70（HR 3.01，95%CI 1.25-7.31，P = 0.014）和较大的BSLD（HR 1.09，95%CI 1.01-1.18，P = 0.021）是具有统计学意义的不良预后的独立预测因素。原发性胆道部位未被确定为预后因素（P = 0.728）。BSLD <9.0cm和> 9.0cm患者的中位生存期分别为18.7和8.8个月（P = 0.024），年龄和BSLD是影响晚期胆道癌化疗预后的重要因素。肿瘤体积可能比原发部位对晚期胆道癌的预后更重要。
Prognostic factors for patients with advanced biliary tract cancer receiving chemotherapy are presently not well established. Gallbladder cancer and intra-hepatic cholangiocarcinoma are previously reported prognostic factors of poor prognosis; however, tumor volume has not been analyzed in these previous reports.We analyzed 56 consecutive patients with advanced biliary tract cancer who had received gemcitabine and S-1 combination chemotherapy as first-line palliative chemotherapy. Prognostic factors, including the baseline sum longest diameter (BSLD) representing tumor volume in Response Evaluation Criteria in Solid Tumor, were evaluated.By multivariate analysis, age a parts per thousand yen70 (HR 3.01, 95% CI 1.25-7.31, P = 0.014) and larger BSLD (HR 1.09, 95% CI 1.01-1.18, P = 0.021) were statistically significant independent predictors of poor prognosis. Primary biliary site was not identified as a prognostic factor (P = 0.728). Median survival times of patients with BSLDs a parts per thousand currency sign 9.0 cm and BSLDs > 9.0 cm were 18.7 and 8.8 months, respectively (P = 0.024).Age and BSLD were identified as strong prognostic factors for patients with advanced biliary tract cancer receiving chemotherapy. Tumor volume might be more important than primary biliary site for the prognosis of advanced biliary tract cancer.