Fatigue in patients with Parkinson's disease
Fatigue in patients with Parkinson's disease
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DOI：
10.1155/2000/580683
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发表时间：
2000-01-01
影响因子：
2.8
通讯作者：
Yanagihara, T
中科院分区：
文献类型：
--
作者：
Abe, K;Takanashi, M;Yanagihara, T
目的：疲劳是帕金森病（PD）患者常见的主诉，但其病理生理机制尚不清楚。研究方法：我们使用疲劳量表评估了26例临床诊断为PD的患者（16例男性，10例女性）和年龄和性别匹配的26例无神经功能缺损的对照组（16例男性，10例女性）的疲劳。除了神经系统和神经心理学检查外，所有患者均使用99 mTc-HMPAO进行MRI和SPECT检查。结果如下：根据MMSE判断，PD患者的认知功能正常，但与对照组相比，疲劳和抑郁量表评分显着较高（p < 0.05）。抑郁量表和疲劳量表之间，或残疾程度和疲劳量表之间的PD患者没有显着的相关性，虽然抑郁量表和疲劳量表之间存在显着的相关性在控制。SPECT发现PD患者的疲劳程度与额叶灌注减少之间存在显著相关性（p < 0.05）。结论：PD患者的疲劳感可能与额叶功能障碍有关。
Purpose: Fatigue is a complaint frequently encountered among patients with Parkinson's disease (PD), however, the pathophysiological mechanism remains unclear. Methods: We evaluated fatigue in 26 patients clinically diagnosed to have PD (16 men, 10 women) and age- and sex- matched 26 controls (16 men, 10 women) without neurological deficits by using a fatigue scale. In addition to neurological and neuropsychological examinations, all patients underwent MRI and SPECT using 99mTc-HMPAO. Results: Patients with PD had normal cognitive function as judged by the MMSE, but showed significantly high scores with the fatigue and depression scales in comparison to controls (p < 0.05). There was no significant correlation between the depression scale and the fatigue scale, or between the degree of disability and the fatigue scale in patients with PD, although a significant correlation existed between the depression scale and the fatigue scale in controls. With SPECT, a significant correlation was found between the fatigue scale and the reduction of perfusion in the frontal lobe (p < 0.05) in patients with PD. Conclusions:: The present study suggested that sense of fatigue in patients with PD might be associated with frontal lobe dysfunction.