The origins of SARS-CoV-2: A critical review.

The origins of SARS-CoV-2: A critical review.
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DOI:
10.1016/j.cell.2021.08.017
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发表时间:
2021-09-16
期刊:
影响因子:
64.5
通讯作者:
Rambaut A
Rambaut A
中科院分区:
生物学1区
文献类型:
--
作者:
Holmes EC;Goldstein SA;Rasmussen AL;Robertson DL;Crits-Christoph A;Wertheim JO;Anthony SJ;Barclay WS;Boni MF;Doherty PC;Farrar J;Geoghegan JL;Jiang X;Leibowitz JL;Neil SJD;Skern T;Weiss SR;Worobey M;Andersen KG;Garry RF;Rambaut A

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Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a “laboratory escape” scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2. A review of the current literature supports a zoonotic origin for SARS-CoV-2 and emphasizes the need to focus on identifying the exact animal host through collaborative and carefully coordinated studies. This will enable the community to understand the roots of the COVID-19 pandemic as well as better prepare us for future pandemics
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