Preliminary investigation of electrothermal vaporization sample introduction for inductively coupled plasma time-of-flight mass spectrometry.
Preliminary investigation of electrothermal vaporization sample introduction for inductively coupled plasma time-of-flight mass spectrometry.
复制标题
电感耦合等离子体飞行时间质谱电热汽化进样的初步研究。
DOI：
10.1021/ac9811625
复制
发表时间：
1999
影响因子：
7.4
通讯作者：
Hieftje,GM
中科院分区：
文献类型：
--
作者：
Mahoney,PP;Ray,SJ;Li,G;Hieftje,GM
介绍了一种电感耦合等离子体飞行时间质谱仪（ICP-TOFMS）与电子蒸发（ETV）装置的耦合。实验证明了ICP-TOFMS在高重复率下产生完整元素质谱的能力。采用信号平均数据采集板快速记录整个蒸发阶段的ETV温度循环的完整元素光谱，含有34个元素的溶液进行了分析。通过炉的温度程序的分子和原子的同量异位素干扰的减少被证明。镉、锡和铟的同位素之间的等压重叠通过利用元素蒸发特性的差异来解决。该系统的品质因数是用能够在TOF仪器的高重复率下操作的几种不同的数据采集方案来定义的。使用离子计数和矩形波串平均器，动态范围被示出为在至少6个数量级的范围内是线性的。一对矩形波串平均器用于测量银的同位素比，其精密度为1.9% RSD，尽管循环间精密度为19% RSD。基于10 μL进样，计算出7种元素的检测限为10−80 fg。
The coupling of an electrothermal vaporization (ETV) apparatus to an inductively coupled plasma time-of-flight mass spectrometer (ICP-TOFMS) is described. The ability of the ICP-TOFMS to produce complete elemental mass spectra at high repetition rates is experimentally demonstrated. A signal-averaging data acquisition board is employed to rapidly record complete elemental spectra throughout the vaporization stage of the ETV temperature cycle; a solution containing 34 elements is analyzed. The reduction of both molecular and atomic isobaric interferences through the temperature program of the furnace is demonstrated. Isobaric overlaps among the isotopes of cadmium, tin, and indium are resolved by exploiting differences in the vaporization characteristics of the elements. Figures of merit for the system are defined with several different data acquisition schemes capable of operating at the high repetition rate of the TOF instrument. With the use of both ion counting and a boxcar averager, the dynamic range is shown to be linear over a range of at least 6 orders of magnitude. A pair of boxcar averagers are used to measure the isotope ratio for silver with a precision of 1.9% RSD, despite a cycle-to-cycle precision of 19% RSD. Detection limits of 10−80 fg are calculated for seven elements, based upon a 10-μL injection.