VITAMIN-D SYNTHESIS AND METABOLISM AFTER ULTRAVIOLET-IRRADIATION OF NORMAL AND VITAMIN-D-DEFICIENT SUBJECTS
VITAMIN-D SYNTHESIS AND METABOLISM AFTER ULTRAVIOLET-IRRADIATION OF NORMAL AND VITAMIN-D-DEFICIENT SUBJECTS
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DOI：
10.1056/nejm198203253061206
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发表时间：
1982-01-01
影响因子：
158.5
通讯作者：
HOLICK, MF
中科院分区：
文献类型：
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作者：
ADAMS, JS;CLEMENS, TL;HOLICK, MF
60 多年来，人们一直认识到阳光对治疗和预防佝偻病和骨软化症的有益作用。1然而，人们对单次接触阳光后维生素 D 及其代谢物血清浓度的连续变化知之甚少。为了了解这些事件，我们监测了正常受试者和维生素 D 缺乏患者在全身暴露于不同剂量的紫外线辐射 (UVR) 之前和之后的三周内维生素 D 及其代谢物、25-羟基维生素 D (25-OH-D) 和 1,25-二羟基维生素 D (1,25-(OH)2-D) 血清浓度的变化。我们发现暴露于 . 。 。
THE beneficial effects of sunlight in the treatment and prevention of rickets and osteomalacia have been recognized for over 60 years.1However, little is known about the sequential changes in the serum concentrations of vitamin D and its metabolites after a single exposure to sunlight. In an attempt to understand these events, we monitored changes in serum concentrations of vitamin D and its metabolites, 25-hydroxyvitamin D (25-OH-D) and 1,25-dihydroxyvitamin D (1,25-(OH)2-D), over a three-week period in normal subjects and vitamin-D-deficient patients, before and after whole-body exposure to various doses of ultraviolet radiation (UVR). We found that exposure to . . .