Japanese Old Stories Cognitive Scale: a screening test to detect cognitive disease and prompt visiting a memory clinic.
Japanese Old Stories Cognitive Scale: a screening test to detect cognitive disease and prompt visiting a memory clinic.
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日本老故事认知量表：一种筛查测试，用于检测认知疾病并提示前往记忆诊所。
DOI：
10.1111/ggi.13883
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Takechi H.
中科院分区：
文献类型：
--
作者：
Honjo Y;Takechi H.
阿尔茨海默病(AD)是最常见的神经退行性疾病。2000年，Mendiondoet等人报告了一个模型，该模型预测阿尔茨海默病的发展速度加快，认知功能迅速恶化。近年来，抗AD药物和非药物干预已被确立，但干预的效果尚不清楚，可能取决于AD的进展阶段。在这里，我们检验了蒙迪昂多模型在不同程度的AD患者中的预测。所有AD患者在首次就诊时和大约12个 月后接受修订的长谷川痴呆量表(HDS-R)和简易精神状态检查(MMSE)。我们根据初诊时的评分将患者分为三组：轻度、中度和中重度。结果经过12个 月的干预后，HDS-R评分由14.5分提高至15.0分，MMSE评分由18.8分提高至19.1分， 评分由治疗前的14.5分提高至15.0分。此外，首次就诊时的HDS-R和MMSE评分与评分的年度变化显著相关。在三组中，初诊时较低的HDS-R和MMSE评分与干预12个月后评分的年度改善显著相关。结论与蒙迪昂多模型的预测相反，在药物和非药物干预下，轻度或中度AD的进展速度快于中至重度AD。
AimAlzheimer's disease (AD) is the most common neurodegenerative disease. In 2000, Mendiondoet al.reported on a model predicting that AD progresses at an accelerating rate and cognitive function worsens rapidly. Recently, anti‐AD drugs and non‐pharmacological intervention have been established, but the effect of intervention is unclear and might depend on the stage of AD progression. Here, we examined the prediction of Mendiondo's model in patients with different severities of AD.MethodsA total of 163 new outpatients with AD at four memory clinics were retrospectively analyzed. The Revised Hasegawa Dementia Scale (HDS‐R) and Mini‐Mental State Examination (MMSE) were administered to all AD patients at the first visit and after approximately 12 months. We divided the patients into three groups according to scores at the first visit: mild, moderate and moderate‐to‐severe. We compared the scores at the first visit with those obtained after 12 months of anti‐AD drug and non‐pharmacological interventions.ResultsThe HDS‐R score improved from 14.5 to 15.0, and the MMSE score improved from 18.8 to 19.1 after 12 months of intervention. Also, the HDS‐R and MMSE scores at the first visit were significantly associated with the annual change in the scores. Among the three groups, lower HDS‐R and MMSE scores at the first visit were associated with significantly greater annual improvement in the scores after 12 months of intervention.ConclusionsContrary to the prediction of Mendiondo's model, mild or moderate AD progressed more rapidly than moderate‐to‐severe AD under pharmacological and non‐pharmacological interventions.Geriatr Gerontol Int 2020; 20: 324–328.