Consequences of exposure measurement error for confounder identification in environmental epidemiology
Consequences of exposure measurement error for confounder identification in environmental epidemiology
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DOI：
10.1002/sim.1541
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发表时间：
2003-10-15
影响因子：
2
通讯作者：
White, RF
中科院分区：
文献类型：
--
作者：
Budtz-Jorgensen, E;Keiding, N;White, RF
已知暴露变量中的非微分测量误差会减弱剂量-反应关系。在给定情况下引入的衰减量不仅是曝光测量精度的函数，而且还取决于给定其他自变量的真实曝光的条件方差。此外，混杂效应也可能受到暴露测量误差的影响。在法罗群岛进行的一项流行病学研究的实例说明了统计模型开发中的这些困难，该研究旨在调查产前汞暴露对健康的不利影响。版权所有（C）2003约翰威利父子有限公司。
Non-differential measurement error in the exposure variable is known to attenuate the dose-response relationship. The amount of attenuation introduced in a given situation is not only a function of the precision of the exposure measurement but also depends on the conditional variance of the true exposure given the other independent variables. In addition, confounder effects may also be affected by the exposure measurement error. These difficulties in statistical model development are illustrated by examples from a epidemiological study performed in the Faroe Islands to investigate the adverse health effects of prenatal mercury exposure. Copyright (C) 2003 John Wiley Sons, Ltd.