P2X receptor-mediated purinergic sensory pathways to the spinal cord dorsal horn.
P2X receptor-mediated purinergic sensory pathways to the spinal cord dorsal horn.
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DOI：
10.1007/s11302-004-4743-6
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发表时间：
2004-12
影响因子：
3.5
通讯作者：
Heft, Marc W
中科院分区：
文献类型：
--
作者：
Gu, Jianguo G;Heft, Marc W
P2X受体在初级传入纤维的不同功能群上表达。P2X受体介导的感觉输入可能是无害的，也可能是有害的，这取决于哪个背角区域接受这些输入。我们简要回顾了P2X受体介导的嘌呤能感觉通路在背角的不同区域。这些P2X嘌呤能途径在正常动物中被发现，这为其生理功能提供了见解。未来对病理动物模型中P2X嘌呤能通路的研究可能会为P2X受体如何在病理性疼痛状态中发挥作用提供见解。
P2X receptors are expressed on different functional groups of primary afferent fibers. P2X receptor-mediated sensory inputs can be either innocuous or nociceptive, depending on which dorsal horn regions receive these inputs. We provide a brief review of P2X receptor-mediated purinergic sensory pathways to different regions in the dorsal horn. These P2X purinergic pathways are identified in normal animals, which provides insights into their physiological functions. Future studies on P2X purinergic pathways in animal models of pathological conditions may provide insights on how P2X receptors play a role in pathological pain states.