A preliminary study on prenatal polybrominated diphenyl ether serum concentrations and intrinsic functional network organization and executive functioning in childhood
A preliminary study on prenatal polybrominated diphenyl ether serum concentrations and intrinsic functional network organization and executive functioning in childhood
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DOI：
10.1111/jcpp.13040
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发表时间：
2019-09-01
影响因子：
7.6
通讯作者：
Horton, Megan K.
中科院分区：
文献类型：
--
作者：
de Water, Erik;Curtin, Paul;Horton, Megan K.
产前是一个易受伤害的时期，在此期间，神经毒性暴露会对大脑发育和行为产生持续的变化。在商业产品中用作阻燃剂的多溴联苯醚（PBDEs）是已知的发育神经毒物。十年前，多溴二苯醚在美国已逐步停止使用，但由于其从现有产品中释放出来以及生物持久性，暴露范围仍然很广。尽管有一致的动物和流行病学证据表明发育性神经毒性，但产前多溴二苯醚血清浓度与神经发育受损之间的神经底物关系尚不清楚。在本研究中，我们使用静息状态功能磁共振成像（fMRI）来检查5岁儿童（n = 34）产前母体血清中PBDE浓度测量与内在功能网络组织（即全局和局部效率；使用图理论方法估计）之间的关系。我们通过父母报告问卷（BRIEF-P） （n = 106）研究了多溴二苯醚（PBDE）血清浓度是否与执行功能（EF）相关，以及内在功能网络组织的变化是否与产前多溴二苯醚（PBDE）血清浓度与EF问题之间的关系有关。结果产前多溴二苯醚血清浓度较高的儿童显示：(a)涉及视觉注意的大脑区域（如枕下回）的整体效率增加（β值= 0.01，fdr校正的p值）
Background The prenatal period is a period of vulnerability during which neurotoxic exposures exert persistent changes in brain development and behavior. Polybrominated diphenyl ethers (PBDEs), used as flame retardants in commercial products, are known to be developmental neurotoxicants. PBDEs were phased out of use in the United States a decade ago, but exposure remains widespread due to their release from existing products and biopersistence. Despite consistent animal and epidemiological evidence of developmental neurotoxicity, the neural substrates linking prenatal PBDE serum concentrations to impaired neurodevelopment are poorly understood. Methods In the present study, we used resting state functional magnetic resonance imaging (fMRI) to examine associations between prenatal PBDE concentrations measured in maternal serum and intrinsic functional network organization (i.e., global and local efficiency; estimated using a graph-theoretical approach) in 5-year-old children (n = 34). We explored whether PBDE serum concentrations were associated with executive functioning (EF) assessed using a parent-report questionnaire (BRIEF-P) (n = 106) and whether changes in intrinsic functional network organization linked the association between prenatal PBDE serum concentrations and EF problems. Results Children with higher prenatal PBDE serum concentrations showed: (a) increased global efficiency of brain areas involved in visual attention (e.g., inferior occipital gyrus) (beta's = .01, FDR-corrected p's