Anxiety sensitivity and illicit sedative use among opiate-dependent women and men.
Anxiety sensitivity and illicit sedative use among opiate-dependent women and men.
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DOI：
10.3109/00952990.2010.535581
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发表时间：
2011-01
期刊：
影响因子：
--
通讯作者：
Otto MW
中科院分区：
文献类型：
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作者：
Hearon BA;Calkins AW;Halperin DM;McHugh RK;Murray HW;Otto MW
研究表明，焦虑敏感度较高的人（对与焦虑相关的良性身体感觉的恐惧）更有可能使用物质来科普痛苦，特别是具有唤醒抑制作用的物质，如苯二氮卓类药物和其他镇静剂。这种应对动机也可能因性别而异，妇女更有可能为应对（自我用药）目的使用药物。鉴于这些发现，我们假设焦虑敏感性（AS）与阿片类药物依赖样本中非法使用镇静剂有关，性别会缓和这种关系，女性之间的关联更大。参与者是从美沙酮维持诊所招募的68名阿片类药物依赖患者。采用逻辑回归分析来确定AS是否与是否存在非法使用镇静剂的历史相关。AS与镇静剂的使用显著相关，这种关系受性别的调节; AS升高仅与女性使用更多镇静剂相关。AS升高的存在与女性更大的非法使用镇静剂有关，但与男性无关。女性可能更容易寻求镇静剂作为应对不愉快，焦虑感觉的手段。
Research has suggested that individuals with elevated anxiety sensitivity (the fear of benign bodily sensations associated with anxiety) are more likely to use substances to cope with distress, particularly substances with arousal-dampening effects such as benzodiazepines and other sedatives. Such coping motives may also vary as a function of gender, with women more likely to use substances for coping (self-medicating) purposes. Given these findings, we hypothesized that anxiety sensitivity (AS) would be associated with illicit sedative use in an opioid-dependent sample and that gender would moderate this relationship, with a greater association among women. Participants were 68 opioid-dependent patients recruited from a methadone maintenance clinic. A logistic regression was used to determine whether AS was associated with presence or absence of a history of illicit sedative use. AS was significantly associated with sedative use and this relationship was moderated by gender; elevated AS was associated with greater sedative use only in women. The presence of elevated AS is related to greater illicit use of sedatives in women but not in men. Women may be more susceptible to seek sedatives as a means of coping with unpleasant, anxious sensations.