Sequential activation of signaling pathways during innate immune responses in Drosophila
Sequential activation of signaling pathways during innate immune responses in Drosophila
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DOI：
10.1016/s1534-5807(02)00325-8
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发表时间：
2002-11-01
影响因子：
11.8
通讯作者：
Perrimon, N
中科院分区：
文献类型：
--
作者：
Boutros, M;Agaisse, H;Perrimon, N
先天免疫对后生动物抵抗微生物感染至关重要。全基因组表达谱用于分析微生物攻击后特定信号通路受损的结果。我们发现这些转录模式可以被分解成不同的组。我们证明，除了通过Toll和lmd途径发出信号外，通过JNK和JAK/STAT途径发出信号控制微生物制剂诱导的不同靶标亚群。每种途径都显示出特定的激活时间模式，并针对不同的功能群，这表明先天免疫反应是模块化的，并招募不同的生理程序。特别是，我们的结果可能意味着组织修复和抗菌过程的控制之间的密切联系。
Innate immunity is essential for metazoans to fight microbial infections. Genome-wide expression profiling was used to analyze the outcome of impairing specific signaling pathways after microbial challenge. We found that these transcriptional patterns can be dissected into distinct groups. We demonstrate that, in addition to signaling through the Toll and lmd pathways, signaling through the JNK and JAK/STAT pathways controls distinct subsets of targets induced by microbial agents. Each pathway shows a specific temporal pattern of activation and targets different functional groups, suggesting that innate immune responses are modular and recruit distinct physiological programs. In particular, our results may imply a close link between the control of tissue repair and antimicrobial processes.