The Epidemiology of Longevity and Exceptional Survival
The Epidemiology of Longevity and Exceptional Survival
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DOI：
10.1093/epirev/mxs013
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发表时间：
2013-02-04
影响因子：
5.5
通讯作者：
Murabito, Joanne M.
中科院分区：
文献类型：
--
作者：
Newman, Anne B.;Murabito, Joanne M.
“长寿流行病学”领域近年来迅速扩大。几项长期的队列研究对老年人进行了足够长的跟踪调查，以确定最长寿的人，并确定导致长寿的许多因素。非常长寿的人，如百岁老人，已经使用病例对照研究设计进行了研究。队列研究和病例对照研究都是全基因组关联研究的主题，这些研究已经确定了与长寿相关的遗传变异。随着人们越来越认识到罕见变异的重要性，长寿的家族研究将是有用的。最近，外显子组和全基因组测序、基因表达和表观遗传学研究已经进行，以更好地定义基因组的功能变异和调控。在这篇综述中，我们考虑这些研究如何导致对长寿的潜在生物学途径的更深入理解。
The field of the "epidemiology of longevity" has been expanding rapidly in recent years. Several long-term cohort studies have followed older adults long enough to identify the most long-lived and to define many factors that lead to a long life span. Very long-lived people such as centenarians have been examined using case-control study designs. Both cohort and case-control studies have been the subject of genome-wide association studies that have identified genetic variants associated with longevity. With growing recognition of the importance of rare variations, family studies of longevity will be useful. Most recently, exome and whole-genome sequencing, gene expression, and epigenetic studies have been undertaken to better define functional variation and regulation of the genome. In this review, we consider how these studies are leading to a deeper understanding of the underlying biologic pathways to longevity.