Heating NiTi stent in magnetic fields and the thermal effect on smooth muscle cells
Heating NiTi stent in magnetic fields and the thermal effect on smooth muscle cells
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DOI：
10.4028/www.scientific.net/kem.288-289.579
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Zhao, LC
中科院分区：
文献类型：
--
作者：
Li, CJ;Zheng, YF;Zhao, LC
本文研究了利用感应加热炉交变磁场加热镍钛支架的可行性，以及高温对平滑肌细胞的影响。电磁场对NiTi支架有明显的加热作用，可以通过改变炉膛电压、加热时间和NiTi支架的位置来调节加热温度。热处理工艺对SMCs的形状和寿命状态有影响。SMCs对热的反应分为三个阶段：(1)当温度低于44℃时，SMCs的生存状态不发生变化；(2)在44℃~ 50℃之间，细胞收缩，台盼蓝染色较少，表明细胞还活着；(3)当温度高于50℃时，细胞全部死亡。我们发现，从44℃到50℃，SMCs凋亡死亡，这可能使我们可以对植入支架进行加热以防止再狭窄。
The feasibility of using an alternating magnetic field from induction heating furnace to heat the NiTi stent and the influence of hyperthermic on smooth muscle cells (SMCs) have been studied in the present work. The electromagnetic field is capable of significantly heating NiTi stents and the heating temperature can be adjusted by changing the voltage and heating time of the furnace and the position of NiTi stents. The shape and living status of SMCs were influenced by the heat treatment procedures. There were three stages of SMCs reaction to heat: (1) when the temperature below 44 degrees C, the living status was not changed; (2) between 44 degrees C to 50 degrees C, the cells shrinked and were less dyed with trypan blue, which indicated that they were still alive; (3) when the temperature was above the 50 degrees C, all the cells died. It was found that from 44 degrees C to 50 degrees C, the SMCs died in apoptosis, which might allow us to heat the implanted stent to prevent restenosis.