Synthesis and Biological Evaluation of Hippolachnin A Analogues
Synthesis and Biological Evaluation of Hippolachnin A Analogues
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DOI：
10.1021/acs.orglett.8b01381
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发表时间：
2018-07-06
期刊：
影响因子：
5.2
通讯作者：
Wood, John L.
中科院分区：
文献类型：
--
作者：
Timmerman, Jacob C.;Wood, John L.
海洋聚酮化合物hippolachnin A（1）由于其复杂的核心结构和对有毒真菌的生物活性而引起了合成化学家的极大关注。本文描述了最近的努力，采用我们最近开发的合成的构效关系研究1。这些研究表明，与最初的报道相反，1和几个结构类似物缺乏对病原真菌的活性。
The marine polyketide hippolachnin A (1) has attracted considerable attention from synthetic chemists due to both its intricate core structure and attractive biological activity against virulent fungi. Described herein are recent efforts to employ our recently developed synthesis in structure activity relationship studies of 1. These studies have revealed that, in contrast to initial reports, 1 and several structural analogues lack activity against pathogenic fungi.