Prospects for research in inflammatory bowel disease
Prospects for research in inflammatory bowel disease
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DOI：
10.1001/jama.285.5.643
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发表时间：
2001-02-07
影响因子：
120.7
通讯作者：
Strober, W
中科院分区：
文献类型：
--
作者：
Blumberg, RS;Strober, W
炎症性肠病是胃肠道的慢性炎症，表现为溃疡性结肠炎和克罗恩病。这两种临床实体都是由相互关联的遗传和环境因素引起的，这些因素可能通过粘膜免疫功能异常而引起，可能是由于辅助性 T 细胞 (T-H)1（克罗恩病）或 T(H)2（溃疡性结肠炎）反应失调或过度所致。本文回顾了免疫因子在炎症性肠病中的作用的最新知识，以及针对 T(H)1 或 T(H)2 诱导炎症途径的潜在治疗策略。
Inflammatory bowel disease is a chronic inflammatory condition of the gastrointestinal tract that manifests as ulcerative colitis and Crohn disease. Both these clinical entities result from interrelated genetic and environmental factors that may be channeled through an abnormality in mucosal immune function, possibly due to dysregulated or excessive T helper cell (T-H)1 (Crohn disease) or T(H)2 (ulcerative colitis) responses. This article reviews current knowledge of the role of immune factors in inflammatory bowel disease and the potential therapeutic strategies that target the pathways of T(H)1- or T(H)2-induced inflammation.