Clock genes, hair growth and aging.

Clock genes, hair growth and aging.
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DOI:
10.18632/aging.100130
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发表时间:
2010-03-31
期刊:
Aging
影响因子:
--
通讯作者:
Andersen B
Andersen B
中科院分区:
其他
文献类型:
--
作者:
Geyfman M;Andersen B

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毛囊经历生长、退化和休止的连续周期。这个过程被称为头发生长周期,周期为几周到几个月。与此同时,皮肤和毛囊拥有一个功能性的生物钟,它以大约24小时的周期调节基因表达。在我们最近的研究中,我们发现生物钟基因在同步毛囊周期的头发生长周期中起着调节作用,揭示了皮肤中这两个定时系统之间意想不到的联系。因此,这项工作表明生物钟基因在一个周期比24小时长得多的周期性过程中的作用。
Hair follicles undergo continuous cycles of growth, involution and rest. This process, referred to as the hair growth cycle, has a periodicity of weeks to months. At the same time, skin and hair follicles harbor a functional circadian clock that regulates gene expression with a periodicity of approximately twenty four hours. In our recent study we found that circadian clock genes play a role in regulation of the hair growth cycle during synchronized hair follicle cycling, uncovering an unexpected connection between these two timing systems within skin. This work, therefore, indicates a role for circadian clock genes in a cyclical process of much longer periodicity than twenty four hours.
DOI: 10.1111/j.1365-2133.1995.tb08630.x
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