Prognostic Value of C-Reactive Protein in Patients With Coronavirus 2019
Prognostic Value of C-Reactive Protein in Patients With Coronavirus 2019
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DOI：
10.1093/cid/ciaa641
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发表时间：
2020-10-15
影响因子：
11.8
通讯作者：
Yang, Weize
中科院分区：
文献类型：
--
作者：
Luo, Xiaomin;Zhou, Wei;Yang, Weize
背景2019冠状病毒病（COVID-19）患者血清C反应蛋白（CRP）水平升高。回顾性收集并分析了2020年1月30日至2020年2月20日期间在中国武汉一家定点医院治疗的COVID-19患者的临床结局数据。评估入院时CRP对COVID-19患者的预后价值。在入组的298例患者中，84例死亡，214例康复。大多数死亡者是男性、老年人或患有慢性疾病。与存活者相比，死亡者的白色血细胞和中性粒细胞计数、中性粒细胞与淋巴细胞比值（NLR）、全身免疫炎症指数（定义为血小板计数乘以NLR）、CRP、降钙素原和D-二聚体显著升高，红细胞、淋巴细胞和血小板计数降低。年龄、中性粒细胞计数、血小板计数和CRP被确定为不良结局的独立预测因素。CRP的受试者工作特征（ROC）曲线下面积（AUC）（0.896）显著高于年龄（0.833）、中性粒细胞计数（0.820）和血小板计数（0.678）（P均0.05）。在COVID-19患者中，入院时CRP与疾病严重程度相关，往往是不良结局的良好预测因子。
Background. An elevated serum C-reactive protein (CRP) level was observed in most patients with coronavirus disease 2019 (COVID-19).Methods. Data for COVID-19 patients with clinical outcome in a designated hospital in Wuhan, China, were retrospectively collected and analyzed from 30 January 2020 to 20 February 2020. The prognostic value of admission CRP was evaluated in patients with COVID-19.Results. Of 298 patients enrolled, 84 died and 214 recovered. Most nonsurvivors were male, older, or with chronic diseases. Compared with survivors, nonsurvivors showed significantly elevated white blood cell and neutrophil counts, neutrophil to lymphocyte ratio (NLR), systemic immune inflammation index (defined by platelet count multiplied by NLR), CRP, procalcitonin, and D-dimer and showed decreased red blood cell, lymphocyte, and platelet counts. Age, neutrophil count, platelet count, and CRP were identified as independent predictors of adverse outcome. The area under the receiver operating characteristic (ROC) curve (AUC) of CRP (0.896) was significantly higher than that of age (0.833), neutrophil count (0.820), and platelet count (0.678) in outcome prediction (all P .05).Conclusions. In patients with COVID-19, admission CRP correlated with disease severity and tended to be a good predictor of adverse outcome.