Controlling interlayer diffusion to achieve sustained, multiagent delivery from layer-by-layer thin films
Controlling interlayer diffusion to achieve sustained, multiagent delivery from layer-by-layer thin films
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DOI：
10.1073/pnas.0602884103
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发表时间：
2006-07-05
影响因子：
11.1
通讯作者：
Hammond, Paula T.
中科院分区：
文献类型：
--
作者：
Wood, Kris C.;Chuang, Helen F.;Hammond, Paula T.
我们提出了制造保形，水解降解薄膜能够管理持续，多药释放曲线。膜是通过使用逐层定向沉积技术一次一个分子层地构建的;这些系统的随后的水解表面侵蚀导致以反映它们在膜中的相对位置的顺序释放并入的材料。每种物质的位置是由其在整个膜结构中扩散的能力决定的，因此，这项工作的主要重点是定义在组装过程中物理阻止层间扩散以产生多组分分层膜的策略。通过使用一系列的放射性标记的聚电解质作为实验探针，我们表明，共价交联的屏障可以有效地阻止层间扩散，导致区室化的结构，虽然即使是非常大量的离子交联（可降解或不可降解）的屏障层不能阻止层间扩散。通过使用这些原理，我们设计了能够延长释放以及并行和串行多药剂释放的可降解膜。制造具有纳米级分辨率的多组分薄膜的能力可能导致许多新材料和应用。
We present the fabrication of conformal, hydrolytically degradable thin films capable of administering sustained, multiagent release profiles. Films are constructed one molecular layer at a time by using the layer-by-layer, directed-deposition technique; the subsequent hydrolytic surface erosion of these systems results in the release of incorporated materials in a sequence that reflects their relative positions in the film. The position of each species is determined by its ability to diffuse throughout the film architecture, and, as such, the major focus of this work is to define strategies that physically block interlayer diffusion during assembly to create multicomponent, stratified films. By using a series of radiolabeled polyelectrolytes as experimental probes, we show that covalently crosslinked barriers can effectively block interlayer diffusion, leading to compartmentalized structures, although even very large numbers of ionically crosslinked (degradable or nondegradable) barrier layers cannot block interlayer diffusion. By using these principles, we designed degradable films capable of extended release as well as both parallel and serial multiagent release. The ability to fabricate multicomponent thin films with nanoscale resolution may lead to a host of new materials and applications.