Differences in decline in GFR with age between males and females. Reference data on clearances of inulin and PAH in potential kidney donors
Differences in decline in GFR with age between males and females. Reference data on clearances of inulin and PAH in potential kidney donors
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DOI：
10.1093/ndt/gfl227
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发表时间：
2006-09-01
影响因子：
6.1
通讯作者：
Berg, Ulla B.
中科院分区：
文献类型：
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作者：
Berg, Ulla B.
背景。为了确保潜在的肾脏供者没有肾脏损害，有准确的方法来评估肾小球滤过率（GFR）是非常重要的。本研究以菊粉清除率为金标准。目的是评价年龄和性别对肾功能的影响，并提供参考数据。对122例潜在的肾脏供者进行了GFR和有效肾血浆流量（ERPF）的研究，其中62例为女性，年龄21-67岁。平均+/- SD GFR和ERPF分别为105 +/- 13和545 +/- 108 ml/min/1.73 m(2)，我们发现男女之间没有差异。然而，当将GFR和ERPF与年龄联系起来时，在20-50岁年龄段的男性中发现GFR和ERPF显著下降，而在女性中则没有。男性供者GFR每十年平均下降8.7 ml/min/1.73 m(2)， ERPF每十年平均下降90 ml/min/1.73 m(2)。有了足够的方法来确定GFR和ERPF，年龄的影响在性别之间有明显的差异。男性在20岁至50岁之间表现出明显的下降，而女性则没有。女性似乎在绝经前受到保护可能是雌激素的作用。这些结果在临床上证实了在大鼠身上发现的结果。
Background. To ensure that potential kidney donors have no renal impairment, it is extremely important to have accurate methods for evaluating the glomerular filtration rate (GFR). The golden standard, clearance of inulin, has been used in the present study. The aim was to evaluate the effects of age and sex on renal function and present reference data.Methods. A total of 122 potential kidney donors, 62 females, aged 21-67 years, were investigated with the GFR and effective renal plasma flow (ERPF) determined by clearances of inulin and para-amino hippurate.Results. The mean +/- SD GFR and ERPF were 105 +/- 13 and 545 +/- 108 ml/min/1.73 m(2), respectively, and we found no difference between the males and females. When relating GFR and ERPF to age, however, a significant decline was found in GFR and ERPF in males, but not in females in the age range of 20-50 years. GFR fell by a mean of 8.7 ml/min/1.73 m(2) and ERPF by 90 ml/min/1.73 m(2) per decade in male donors.Conclusion. With adequate methods for determining GFR and ERPF, a clear difference in the effect of age was seen between the sexes. Males showed a significant decrease between 20 and 50 years of age, which was not seen in females. Females seem to be protected in the pre-menopausal period probably by oestrogens. These results confirm clinically those found in rats.