Total energy expenditure in the elderly
Total energy expenditure in the elderly
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DOI：
10.1038/sj.ejcn.1601030
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发表时间：
2000-06-01
影响因子：
4.7
通讯作者：
Stubbs, RJ
中科院分区：
文献类型：
--
作者：
Elia, M;Ritz, P;Stubbs, RJ
慢性疾病和残疾随着年龄的增长而增加，影响了超过60%的75岁以上的人，并限制了其中一半人的活动。因此，总能量消耗（TEE）及其组成部分在健康和疾病中分别进行评估。对“健康”受试者中568个双标记水测量值（65岁以上受试者中184个测量值）的分析表明，男性（标准体重75 kg）和女性（标准体重67 kg）分别减少0.69和0.43 MJ/天/十年。体力活动（PA）占TEE下降的46%，基础代谢率（BMR）占下降的44%，产热（T）占剩余的10%。60岁以上的150名男性和100名女性的TEE分别为10.79 ± 2.09和8.62 ± 1.49 MJ/天。在TEE的总方差中，用双标记水在2周内测量，69%被认为是由于个体间的差异，31%是由于个体内的差异。PA加T的方差是BMR的三倍。生理因素对TEE、BMR和PA+T测量的影响远大于方法学因素。对患有各种疾病的自由生活老年患者的136次TEE（双标记水和碳酸氢盐-尿素法）测量结果的分析表明，尽管BMR增加，但TEE经常下降。这在很大程度上是由于PA的减少（例如减少高达50%），但在某些情况下，这也是由于BMR（体重减轻）的减少。需要关于TEE及其组成部分的更全面的信息，部分原因是在招募参与特定示踪剂研究的受试者时可能存在选择偏倚，部分原因是不同疾病和因素在同一疾病过程中的不同时间起作用的可变效应。
Chronic diseases and disabilities increase with age, affecting more than 60% of those over 75 y, and limiting activities in about half of them. Therefore, total energy expenditure (TEE) and its components are assessed separately in health and disease. An analysis of 568 doubly labelled water measurements in 'healthy' subjects (184 measurements in subjects over 65 years) suggests that there is a decrease of 0.69 and 0.43 MJ/day/decade respectively in men (standard weight 75 kg) and women (standard weight 67 kg). Physical activity (PA) accounted for 46% of the decrease in TEE, basal metabolic rate (BMR) for 44% of the decrease and thermogenesis (T) for the remaining 10%. TEE was found to be 10.79 +/- 2.09 and 8.62 +/- 1.49 MJ/day in 150 men and 100 women aged over 60 y, respectively. Of the total variance in TEE, measured with doubly labelled water over a 2 week period, 69% was considered to be due to differences between individuals, and 31% to differences within individuals. The variance due to PA plus T was threefold greater than that due to BMR. Physiological factors were far more important than methodological factors in influencing measurements of TEE, BMR and PA+T. An analysis of 136 measurements of TEE (doubly labelled water and bicarbonate-urea methods) in free-living elderly patients suffering from a variety of diseases suggests a frequent decrease in TEE, which may occur despite an increase in BMR. This is largely due to a reduction is PA (eg up to similar to 50% reduction), but in some cases it is also due to a reduction in BMR (loss of body weight). More comprehensive information is required about TEE and its components, partly because of a probable selection bias in recruitment of subjects participating in specific tracer studies, and partly because of the variable effects of different diseases and factors that operate at different times in the course of the same disease.