Renal Revascularization Attenuates Myocardial Mitochondrial Damage and Improves Diastolic Function in Pigs with Metabolic Syndrome and Renovascular Hypertension.
Renal Revascularization Attenuates Myocardial Mitochondrial Damage and Improves Diastolic Function in Pigs with Metabolic Syndrome and Renovascular Hypertension.
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肾脏血运重建会减弱心肌线粒体损伤，并改善代谢综合征和肾血管高血压的猪的舒张功能。
DOI：
10.1007/s12265-021-10155-3
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发表时间：
2022-03
影响因子：
3.4
通讯作者：
Eirin A
中科院分区：
文献类型：
--
作者：
Farahani RA;Yu S;Ferguson CM;Zhu XY;Tang H;Jordan KL;Saadiq IM;Herrmann SM;Chade AR;Lerman A;Lerman LO;Eirin A
经皮腔内肾血管成形术（PTRA）可以改善肾血管性高血压（RVH）的心脏功能，但其对心脏损伤生物学机制的影响仍不清楚。我们假设 PTRA 恢复肾功能可改善患有代谢综合征 (MetS) 和 RVH 的猪的心肌线粒体损伤并保留心脏功能。对猪进行了 16 周的 MetS+RVH、4 周前用 PTRA 处理的 MetS+RVH 以及 Lean 和 MetS Sham 对照（各 n=6）的研究。通过多排CT评估心脏功能，而离体评估心脏线粒体形态和功能、微血管重塑和损伤途径。 PTRA 减轻心肌线粒体损伤，改善毛细血管和微血管成熟度，改善氧化应激和纤维化，与左心室重构和舒张功能障碍的减弱相关。心肌线粒体损伤与心肌损伤和肾功能障碍相关。用 PTRA 保护心肌线粒体可以增强心脏恢复，强调其在实验性 MetS+RVH 中的治疗潜力。
Percutaneous transluminal renal angioplasty (PTRA) may improve cardiac function in renovascular hypertension (RVH), but its effect on the biological mechanisms implicated in cardiac damage remains unknown. We hypothesized that restoration of kidney function by PTRA ameliorates myocardial mitochondrial damage and preserves cardiac function in pigs with metabolic syndrome (MetS) and RVH. Pigs were studied after 16 weeks of MetS+RVH, MetS+RVH treated 4 weeks earlier with PTRA, and Lean and MetS Sham controls (n=6 each). Cardiac function was assessed by multi-detector CT, whereas cardiac mitochondrial morphology and function, microvascular remodeling, and injury pathways were assessed ex vivo. PTRA attenuated myocardial mitochondrial damage, improved capillary and microvascular maturity, and ameliorated oxidative stress and fibrosis, in association with attenuation of left ventricular remodeling and diastolic dysfunction. Myocardial mitochondrial damage correlated with myocardial injury and renal dysfunction. Preservation of myocardial mitochondria with PTRA can enhance cardiac recovery, underscoring its therapeutic potential in experimental MetS+RVH.
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影响因子：
4.9
作者：
Eirin A;Williams BJ;Ebrahimi B;Zhang X;Crane JA;Lerman A;Textor SC;Lerman LO
通讯作者：
Lerman LO
DOI：
10.1161/hypertensionaha.116.07849
发表时间：
2016-08
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Eirin A;Saad A;Tang H;Herrmann SM;Woollard JR;Lerman A;Textor SC;Lerman LO
通讯作者：
Lerman LO
影响因子：
10.6
作者：
Duchen, Michael R.
通讯作者：
Duchen, Michael R.
影响因子：
3.7
作者：
Holmuhamedov EL;Oberlin A;Short K;Terzic A;Jahangir A
通讯作者：
Jahangir A
影响因子：
8.3
作者：
Eirin, Alfonso;Li, Zilun;Lerman, Lilach O.
通讯作者：
Lerman, Lilach O.