Effect of ambient temperature on the proliferation of brown adipocyte progenitors and endothelial cells during postnatal BAT development in Syrian hamsters.
Effect of ambient temperature on the proliferation of brown adipocyte progenitors and endothelial cells during postnatal BAT development in Syrian hamsters.
复制标题
环境温度对叙利亚仓鼠出生后 BAT 发育过程中棕色脂肪细胞祖细胞和内皮细胞增殖的影响。
DOI：
10.1007/s12576-018-0606-8
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Kazuhiro
中科院分区：
文献类型：
--
作者：
Nagaya Kazuki、 Okamatsu-Ogura Yuko、 Nio-Kobayashi Junko、 Nakagiri Shohei、 Tsubota Ayumi、 Kimura;Kazuhiro
在叙利亚仓鼠中，棕色脂肪组织（BAT）通过棕色脂肪祖细胞的增殖和分化在出生后发育。在这里报告的研究中，我们调查了环境温度如何影响新生仓鼠BAT的形成。在23或30 °C饲养的两只仓鼠中，肩胛间脂肪以年龄依赖性方式从白色变为棕色，并在第16天获得BAT的典型形态学特征。然而，在30 °C升高的组中，解偶联蛋白1（棕色脂肪细胞标记物）和血管内皮生长因子α的表达低于在23 °C升高的组。免疫荧光染色显示，30 °C组中表达Ki67的祖细胞和内皮细胞的比例低于23 °C组。这些结果表明，温暖的环境温度抑制棕色脂肪祖细胞和内皮细胞的增殖，并对叙利亚仓鼠BAT的出生后发育产生负面影响。
In Syrian hamsters, brown adipose tissue (BAT) develops postnatally through the proliferation and differentiation of brown adipocyte progenitors. In the study reported here, we investigated how ambient temperature influenced BAT formation in neonatal hamsters. In both hamsters raised at 23 or 30 °C, the interscapular fat changed from white to brown coloration in an age-dependent manner and acquired the typical morphological features of BAT by day 16. However, the expression of uncoupling protein 1, a brown adipocyte marker, and of vascular endothelial growth factor α were lower in the group raised at 30 °C than in that raised at 23 °C. Immunofluorescent staining revealed that the proportion of Ki67-expressing progenitors and endothelial cells was lower in the 30 °C group than in the 23 °C group. These results indicate that warm ambient temperature suppresses the proliferation of brown adipocyte progenitors and endothelial cells and negatively affects the postnatal development of BAT in Syrian hamsters.