SCALE OF BODY PATTERN ADJUSTS TO AVAILABLE CELL NUMBER IN AMPHIBIAN EMBRYOS
SCALE OF BODY PATTERN ADJUSTS TO AVAILABLE CELL NUMBER IN AMPHIBIAN EMBRYOS
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DOI：
10.1038/290775a0
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发表时间：
1981-01-01
期刊：
影响因子：
64.8
通讯作者：
COOKE, J
中科院分区：
文献类型：
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作者：
COOKE, J
在许多胚胎中，其后代通常会形成整个身体模式的细胞被移除后，显然是正常的形态发生，这意味着在其潜力受到限制之前，剩余细胞的活动将进行有序的重新调整。在这样的胚胎中，特殊的细胞谱系不能低估模式的产生和调节1，2。相反，有人提出，在发育中的胚胎中必须有某种调控通讯系统，该系统通常确保适当的空间分化模式，但也能够在足够早的阶段3-6适应物质的移除、添加或移位。最近提出了这种机制的精确模型6-10，并在10-14进行了实验测试。我在肠囊前胚胎阶段对两种遥远的两栖动物类型进行了手术操作，并报告了从模式比例方面所实现的调控效果的评估。这一结果对大多数现有的模式控制理论来说是有问题的。
In many embryos, the removal of cells whose descendants would normally have formed entire parts of the body pattern Is followed by apparently normal morphogenesis, which implies an ordered readjustment of the activities of the remaining cells before their potentialities become restricted. Special cell lineages cannot underly the generation and regulation of pattern in such embryos1,2. It is proposed instead that there must be some regulatory communication system in the developing embryo that normally ensures an appropriate spatial pattern of differentiation but which is also able to adjust to the removal, addition or transposition of material at a sufficiently early stage3–6. Precise models for such a mechanism have recently been suggested6–10, and have been tested experimentally10–14. I have performed surgical manipulations at pre-gastrula embryonic stages in two distantly related amphibian types,XenopusandAmbystoma, and report here an assessment of the regulation achieved in terms of pattern proportions. The results are problematical for most current theories of pattern control.