A226V mutation in virus during the 2007 chikungunya outbreak in Kerala, India
A226V mutation in virus during the 2007 chikungunya outbreak in Kerala, India
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DOI：
10.1099/vir.0.83628-0
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发表时间：
2008-08-01
影响因子：
3.8
通讯作者：
Jambulingam, P.
中科院分区：
文献类型：
--
作者：
Kumar, N. Pradeep;Joseph, Rajan;Jambulingam, P.
2007 年，印度喀拉拉邦再次大面积爆发基孔肯雅病毒 (CHIKV) 感染。在此，我们报告了此次疫情期间从该邦三个受影响最严重地区收集的分离株中，病毒糖蛋白包膜 1 (Ell) 基因出现 A226V 突变。这种突变已被认为是白纹伊蚊 CHIKV 感染性显着增加的直接原因。 2007年喀拉拉邦受灾严重的地区有丰富的橡胶种植园，支持了白纹伊蚊的大量繁殖。白纹伊蚊。 Ae 丰富。该地区的白纹伊蚊和 CHIKV 的分子进化可能是导致 2007 年基孔肯雅热再次流行的因素。
Kerala State in India was gripped by a renewed and widespread outbreak of Chikungunya virus (CHIKV) infection during 2007. Here, we report the A226V mutation in the glycoprotein envelope 1 (Ell) gene of the virus among isolates collected from the three worst-affected districts of the state during this outbreak. This mutation had already been suggested to be directly responsible for a significant increase in CHIKV infectivity in Aedes albopictus. The badly affected districts in Kerala State during 2007 have abundant rubber plantations, which supported prolific breeding of Ae. albopictus mosquitoes. The abundance of Ae. albopictus in the region and molecular evolution of CHIKV may be contributing factors for the renewed epidemic of chikungunya fever during 2007.