A New Resveratrol Hexamer from Upuna borneensis
A New Resveratrol Hexamer from Upuna borneensis
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来自乌普纳婆罗洲的新白藜芦醇六聚体
DOI：
10.3987/com-03-9917
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发表时间：
2004
期刊：
影响因子：
0.6
通讯作者：
M. Iinuma
中科院分区：
文献类型：
--
作者：
Tetsuro Ito;Toŝhiyuki Tanaka;Z. Ali;Y. Akao;Y. Nozawa;Yoshikazu Takahashi;R. Sawa;K. Nakaya;J. Murata;D. Darnaedi;M. Iinuma
从龙脑香科乌普那树（Upuna Dipterocarpaceae）茎的丙酮可溶部分中分离得到一种新的白藜芦醇六聚体乌普那酚A（upunaphenol A）。通过一维和二维核磁共振波谱实验，确定了该化合物的结构，即在一个二苯并双环[3.2.1]辛环和四个二氢苯并呋喃环的部分结构上有12个不对称碳原子。白藜芦醇和四种已知的白藜芦醇低聚物，蛇葡萄素F，异蛇葡萄素F，vaticanols C和B，也被分离。乌普酚A通过诱导HL 6 0细胞凋亡抑制HL 6 0细胞生长，IC5 0为9.2 μM。
A new resveratrol hexamer, upunaphenol A, was isolated from an acetone soluble part of stem of Upuna borneensis (Dipterocarpaceae). The structure, which has twelve asymmetric carbon atoms on the partial structures of a dibenzobicyclo[3.2.1]octadiene ring and four dihydrobenzofuran rings, was determined by spectral analysis including 1D and 2D NMR spectral experiments. Resveratrol and four known resveratrol oligomers, ampelopsin F, isoampelopsin F, vaticanols C and B, were also isolated. Upunaphenol A was found to suppress cell growth in HL60 cells through induction of apoptosis with IC 5 0 at 9.2 μM.