Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications.
Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications.
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DOI：
10.1016/j.bcp.2011.07.093
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发表时间：
2011-12-15
影响因子：
5.8
通讯作者：
Srivastava RK
中科院分区：
文献类型：
--
作者：
Singh BN;Shankar S;Srivastava RK
越来越多的临床前证据表明，在绿色茶（茶树）中发现的主要儿茶素EGCG有可能影响各种人类疾病。显然，EGCG作为一种强大的抗氧化剂，防止健康细胞的氧化损伤，但也作为一种抗血管生成和抗肿瘤剂，并作为肿瘤细胞对化疗反应的调节剂。绿色茶的许多癌症化学预防特性是由EGCG介导的，其通过改变细胞周期调节蛋白的表达、激活杀伤性半胱天冬酶、抑制致癌转录因子和多能性维持因子来诱导细胞凋亡并促进细胞生长停滞。体外研究表明，EGCG通过影响广泛的信号转导途径，包括JAK/STAT，MAPK，PI 3 K/AKT，Wnt和Notch来阻断致癌作用。表没食子儿茶素没食子酸酯通过抑制端粒酶活性促进端粒断裂。各种临床研究表明，EGCG治疗可抑制不同器官部位（如肝、胃、皮肤、肺、乳腺和结肠）的肿瘤发生率和多样性。最近的研究表明，EGCG降低DNMT，蛋白酶和DHFR活性，这将影响TSGs的转录和蛋白质合成。由于其安全、价廉、生物利用度高，在癌症预防方面有很大的潜力。在这篇综述中，我们讨论了它的预防癌症的特性和它的作用机制，在许多点调节癌细胞的生长，存活，血管生成和转移。因此，无毒天然试剂可单独使用或与常规治疗剂组合使用，用于预防肿瘤进展和/或治疗人恶性肿瘤。
An expanding body of preclinical evidence suggests EGCG, the major catechin found in green tea (Camellia sinensis), has the potential to impact a variety of human diseases. Apparently, EGCG functions as a powerful antioxidant, preventing oxidative damage in healthy cells, but also as an antiangiogenic and antitumor agent and as a modulator of tumor cell response to chemotherapy. Much of the cancer chemopreventive properties of green tea are mediated by EGCG that induces apoptosis and promotes cell growth arrest by altering the expression of cell cycle regulatory proteins, activating killer caspases, and suppressing oncogenic transcription factors and pluripotency maintain factors. In vitro studies have demonstrated that EGCG blocks carcinogenesis by affecting a wide array of signal transduction pathways including JAK/STAT, MAPK, PI3K/AKT, Wnt and Notch. EGCG stimulates telomere fragmentation through inhibiting telomerase activity. Various clinical studies have revealed that treatment by EGCG inhibits tumor incidence and multiplicity in different organ sites such as liver, stomach, skin, lung, mammary gland and colon. Recent work demonstrated that EGCG reduced DNMTs, proteases, and DHFR activities, which would affect transcription of TSGs and protein synthesis. EGCG has great potential in cancer prevention because of it’s safety, low cost and bioavailability. In this review, we discuss its cancer preventive properties and it’s mechanism of action at numerous points regulating cancer cell growth, survival, angiogenesis and metastasis. Therefore, non-toxic natural agent could be useful either alone or in combination with conventional therapeutics for the prevention of tumor progression and/or treatment of human malignancies.
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DOI：
10.1124/jpet.103.059220
发表时间：
2004-02-01
影响因子：
3.5
作者：
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通讯作者：
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发表时间：
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影响因子：
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作者：
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