Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease
Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease
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DOI：
10.1016/s0015-0282(03)00571-5
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发表时间：
2003-07-01
影响因子：
6.7
通讯作者：
Serteser, M
中科院分区：
文献类型：
--
作者：
Fenkci, V;Fenkci, S;Serteser, M
目的：通过蛋白羰基水平和总抗氧化状态（TAOS）检测氧化应激水平，以及氧化应激是否与多囊卵巢综合征（PCOS）女性心血管疾病风险增加相关。设计：对照临床研究。单位：大学医院。患者：30名多囊卵巢综合征女性和31名健康对照女性。干预措施：生物特征测量和血液样本采集，主要结果测量：测量c反应蛋白（CRP）、脂质组分、葡萄糖、蛋白羰基、胰岛素和其他激素（促性腺激素、雄激素）水平和TOAS。胰岛素抵抗的估计是通过稳态模型评估（HOMA-R）计算的。结果：多囊卵巢综合征患者血清空腹胰岛素、CRP、蛋白羰基水平、HOMA-R水平、LH水平和LH/FSH比值明显高于健康女性。然而，PCOS女性的TAOS明显较低。TAOS与空腹胰岛素、HOMA-R、CRP和蛋白羰基呈负相关。空腹胰岛素与蛋白羰基正相关。高密度脂蛋白（HDL）与空腹胰岛素、HOMA-R和蛋白羰基呈负相关。结论：除了胰岛素抵抗、高血压、中心性肥胖和血脂异常等已知危险因素外，氧化应激增加和抗氧化能力下降可能导致PCOS女性心血管疾病风险增加。(C) 2003年，美国生殖医学学会。
Objective: To determine oxidative stress by the level of protein carbonyls and total antioxidant status (TAOS), and whether oxidative stress is associated with increased risk of cardiovascular disease in women with polycystic ovary syndrome (PCOS).Design: Controlled clinical study.Setting: University hospital.Patient(s): Thirty women with PCOS and 31 healthy control women.Intervention(s): Biometric measures and blood samples collection,Main Outcome Measure(s): C-reactive protein (CRP), lipid fractions, glucose, protein carbonyls, insulin, and other hormone (gonadotropins, androgens) levels and TOAS were measured. The estimate of insulin resistance was calculated by homeostasis model assessment (HOMA-R).Result(s): The women with PCOS had significantly higher serum fasting insulin, CRP, protein carbonyl levels, HOMA-R, LH levels, and LH/FSH ratios than healthy women. However, TAOS was significantly lower in women with PCOS. TAOS was negatively correlated with fasting insulin, HOMA-R, CRP, and protein carbonyls. Fasting insulin was positively correlated with protein carbonyls. High density lipoprotein (HDL) was inversely associated with fasting insulin, HOMA-R, and protein carbonyls.Conclusion(s): Increased oxidative stress and decreased antioxidant capacity may contribute to the increased risk of cardiovascular disease in women with PCOS, in addition to known risk factors such as insulin resistance, hypertension, central obesity, and dyslipidemia. (C) 2003 by American Society for Reproductive Medicine.