The effect of cataract surgery on blue-yellow and standard-pattern visual-evoked potentials
The effect of cataract surgery on blue-yellow and standard-pattern visual-evoked potentials
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DOI：
10.1007/s00417-014-2728-x
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发表时间：
2014-11-01
影响因子：
2.7
通讯作者：
Mazinani, Babac
中科院分区：
文献类型：
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作者：
Fuest, Matthias;Plange, Niklas;Mazinani, Babac
蓝黄色视觉诱发电位 (BY-VEP) 可用于诊断青光眼和其他眼部疾病中的功能性神经节细胞损伤。在这项研究中，我们通过检查白内障手术前后的患者，研究了晶状体混浊对 BY 和标准模式反转 VEP 的影响。一项前瞻性研究纳入了 18 名中度白内障患者。瞬态开/关等亮度蓝-黄 2A 度检查用于短波长刺激 (BY-VEP)，瞬态大 1A 度 (M1) 和小 0.25A 度 (M2) 黑白检查用于标准模式反转 VEP。 VEP 是在白内障手术前（24 A +/- 30 天）和白内障手术后（14 A +/- 16 天）获得的。以对侧眼作为对照，术前术后M1、M2峰的振幅和潜伏期无明显变化。白内障手术后 BY-VEP 的幅度没有显着变化（手术前，-7.42 +/- 3.43 mu V，手术后，-7.93 +/- 3.65 mu V，p = 0.42），但主要负峰的潜伏期显着降低（手术前，143.9 +/- 12.9 ms，手术后，133.2） +/- 7.7 毫秒，p = 0.0006）。白内障手术前后 BCVA 改善显着（手术前，0.344 +/- 0.125 LogMAR，手术后，0.224 +/- 0.179 LogMAR，p = 0.013），但与手术后 BY-VEP 潜伏期的绝对减少无关（r = 0.309，p = 0.22）。对侧眼没有发现显着变化。BY-VEP 对人类晶状体的晶状体混浊敏感，可能是由于老化眼中短波长吸收的增加。在应用 BY-VEP 进行诊断时应考虑这一事实。
Blue-yellow visual-evoked potentials (BY-VEPs) may be used for diagnostics of functional ganglion cell damage in glaucoma and other ocular diseases. In this study we investigated the impact of lenticular opacities on BY- and standard pattern reversal VEPs by examining patients before and after cataract surgery.Eighteen patients with moderate cataract were included in a prospective study. Transient on/off isoluminant blue-yellow 2A degrees checks were used for short-wavelength stimulation (BY-VEP), transient large 1A degrees (M1) and small 0.25A degrees (M2) black-white checks for standard pattern reversal VEPs. VEPs were acquired before (24 A +/- 30 days) and after cataract surgery (14 A +/- 16 days). The contralateral eye was used as a control.Amplitude and latency of M1 and M2 peaks did not change significantly from before to after surgery. The amplitude of the BY-VEPs did not change significantly after cataract surgery (pre-surgery, -7.42 +/- 3.43 mu V, post-surgery, -7.93 +/- 3.65 mu V, p = 0.42), yet the latency of the main negative peak showed a significant decrease (pre-surgery, 143.9 +/- 12.9 ms, post-surgery, 133.2 +/- 7.7 ms, p = 0.0006). The BCVA improvement was significant from before to after cataract surgery (pre-surgery, 0.344 +/- 0.125 LogMAR, post-surgery, 0.224 +/- 0.179 LogMAR, p = 0.013) yet not correlated to the absolute decrease in latency of the BY-VEP after surgery (r = 0.309, p = 0.22). No significant changes were found in the contralateral eye.The BY-VEP is sensitive to lenticular opacities of the human lens, presumably due to the increased short-wavelength absorption in the aging eye. This fact should be considered when applying BY-VEPs for diagnostics.