MODE OF ACTION OF SELENIUM IN RELATION TO BIOLOGICAL ACTIVITY OF TOCOPHEROLS.
MODE OF ACTION OF SELENIUM IN RELATION TO BIOLOGICAL ACTIVITY OF TOCOPHEROLS.
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硒与生育酚生物活性相关的作用方式。
DOI：
10.1016/0003-9861(65)90124-4
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发表时间：
1965
影响因子：
3.9
通讯作者：
M. L. Scott
中科院分区：
文献类型：
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作者：
I. D. Desai;M. L. Scott
低于1ppm的膳食硒对营养性肌营养不良有部分有益的影响，但如果硒水平较高，则无效或有害。硒在提高维生素E有效性方面的作用至少部分是由于膳食中的硒增加了α-生育酚，特别是d-α-生育酚的保留率。这一点已通过对血浆生育酚的化学测定以及对单独和联合接受这些营养的雏鸡血清和血清蛋白不同部分中氚生育酚和硒75的活性的追踪而得到证明。在血清蛋白中，Se75和H3-α-生育酚的活性非常紧密地跟踪。这些研究表明，维生素E可能是由与血清γ球蛋白相关的一种硒脂蛋白组分携带的。因此，硒的一个生物学作用似乎在于一种含硒化合物，它作为维生素E的载体，可能起到吸收、保留、防止破坏，并可能跨细胞膜转移d-α-生育酚的作用，从而增强其在血液中的生物活性，或许在全身细胞中也是如此。
Dietary selenium at levels below 1 ppm has a partially beneficial effect upon nutritional muscular dystrophy but is ineffective or detrimental at higher levels. The role of selenium in improving the effectiveness of vitamin E is due at least in part to the fact that dietary selenium increases the retention of the α-tocopherols, especiallyd-α-tocopherol. This has been shown by chemical determination of plasma tocopherols and also by tracing the activities of tritiated tocopherols and selenium75in serum and in various fractions of serum proteins in chicks receiving these nutrients alone and in combination.Se75and H3-α-tocopherol activities followed each other very closely in the serum proteins. These studies indicated that vitamin E may be carried by a selenolipoprotein fraction associated with serum γ-globulin. Thus, one biological role of selenium appears to lie in a selenium-containing compound which acts as a carrier of vitamin E and which may function in absorption, retention, prevention of destruction, and perhaps transfer across cell membranes ofd-α-tocopherol, thereby enhancing its biological activity in the blood and perhaps in cells throughout the body.