Contributions of acetylcholine and nitric oxide to forearm blood flow at exercise onset and recovery.
Contributions of acetylcholine and nitric oxide to forearm blood flow at exercise onset and recovery.
复制标题
乙酰胆碱和一氧化氮对运动开始和恢复时前臂血流的贡献。
DOI：
10.1152/ajpheart.1997.273.5.h2388
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Joyner,MJ
中科院分区：
文献类型：
--
作者：
Shoemaker,JK;Halliwill,JR;Hughson,RL;Joyner,MJ
本文研究了八名受试者在轻度运动开始和恢复时，乙酰胆碱和/或一氧化氮（NO）对人前臂血流（FBF）快速变化的贡献。在肱动脉输注生理盐水（2 ml/min;对照）、阿托品（0.2 mg，3 min）以阻断乙酰胆碱与毒蕈碱受体结合，或阿托品+NG-单甲基-L-精氨酸（1-NMMA; 4 mg/min，4 min）以额外抑制NO合酶的过程中进行有节律的手柄收缩。连续测量肱动脉平均血流速度（MBV;脉冲多普勒超声）和直径（回声多普勒），并计算FBF。阿托品可使乙酰胆碱诱导的FBF增加减少0.71%（P< 0.05）。静息时FBF被阿托品降低，并且被阿托品+l-NMMA进一步降低。与对照组相比，两种药物条件均使运动期间的FBF降低了约10%，药物治疗之间没有差异。通过运动、恢复和药物治疗，肱动脉直径与休息时相比没有变化。两种药物治疗都没有改变FBF高于休息时的增加速率或幅度。阿托品和阿托品+l-NMMA可降低运动后FBF峰值。与对照组和阿托品组相比，阿托品+l-NMMA组在5分钟恢复期间的总FBF减少。结果表明：1）乙酰胆碱和NO机制对静息时FBF水平有相加作用; 2）胆碱能机制调节运动时FBF的绝对水平; 3）乙酰胆碱和NO对观察运动反应的正常时程和幅度都不是必需的;
The contributions of acetylcholine and/or nitric oxide (NO) to the rapid changes in human forearm blood flow (FBF) at the onset and recovery from mild exercise were studied in eight subjects. Rhythmic handgrip contractions were performed during brachial artery infusions of saline (2 ml/min; control), atropine (0.2 mg over 3 min), to block acetylcholine binding to muscarinic receptors, or atropine +NG-monomethyl-l-arginine (l-NMMA; 4 mg/min for 4 min), to additionally inhibit NO synthase. Brachial artery mean blood velocity (MBV; pulsed Doppler ultrasound) and diameter (echo Doppler) were measured continuously, and FBF was calculated. Atropine reduced acetylcholine-induced increases in FBF by ∼71% (P< 0.05). FBF at rest was reduced by atropine and further reduced with atropine +l-NMMA. Both drug conditions reduced FBF during exercise by ∼10% compared with control, with no difference between drug treatments. Brachial artery diameter was unchanged from rest by exercise, recovery, and drug treatments. Neither drug treatment altered the rate or magnitude of the increase in FBF above rest. Peak FBF after exercise was reduced by atropine and atropine +l-NMMA. Total FBF during 5 min of recovery was reduced with atropine +l-NMMA compared with control and atropine. The results suggest that1) acetylcholine and NO mechanisms additively contribute to FBF levels at rest,2) a cholinergic mechanism adjusts the absolute FBF levels during exercise,3) neither acetylcholine nor NO is essential to observe the normal time course or magnitude of the exercise response, and4) NO contributes to the FBF response during recovery from exercise.
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